26 results
diagnosis differential hematology treatment neurology algorithm dyspnea hemeonc hemolytic hemophagocytic hlh lymphohistiocytosis mds myelodysplastic pulmonary summary abg acid acidbase activation
Acute and Chronic Causes of Dyspnea - Differential Diagnosis Pulmonary/Chest Wall: • Acute: Trauma, COPD exacerbation, Asthma
Acute and Chronic Causes ... Tamponade • Chronic: Anemia ... hernia, Obesity CNS ... Encephalitis • Chronic: ALS ... Acute #Chronic #Causes
Dyspnea - Differential Diagnosis Framework Cardiovascular Causes of Dyspnea: • Myocardium: - Heart failure - CAD/ACS - Valvulopathy • Electrical: -
- Asthma - COPD ... Hepatopulmonary syndrome ... Guillain Barre - ALS ... Transverse myelitis • Hematology ... : - Anemia •
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
extramedullary disease ... involvement • 30%: CNS ... : CNS manifestations ... - infiltrates (anemia ... #Oncology #Diagnosis
Hypoxemia / Hypoxia - Rapid Response Management Algorithm Stridor - Upper airway pathology: • Anaphylaxis • Foreign
Rapid Response Management ... asthma • Pleural disease ... Hypoventilation: • CNS ... e.g., GBS, MG, ALS ... differential #Diagnosis #Management
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Extravascular Causes ... ) - HELLP syndrome ... ) (e.g. lupus, CLL ... (e.g. primary cold ... #anemia
Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
Lymphoma (HCV) • CLL ... Scleromyxedema (CNS ... (-) hemolytic anemia ... due to cold IgG ... Differential #Diagnosis #Oncology
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
Agglutinin Syndrome ... (CAS): - Due ... • Symptoms of anemia ... hemolysis • C3↓ C4 ... #hematology #diagnosis
Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
Myelodysplastic Syndrome ... diagnosis: 70 years old ... , ~10,000 new cases ... cytopenias (usually anemia ... #oncology
Multiple Cranial Neuropathies - High Yield Differential Diagnosis • Intrinsic brainstem process • Compressive brainstem process
Neurosarcoidosis • CNS ... Lyme Disease, TB ... Miller Fisher Syndrome ... variant-GBS • Bulbar ALS ... Differential #Diagnosis #causes
Summary of Oncologic Emergencies Neutropenic fever: - Fever + ANC < 500 → start cefepime ± vancomycin (if
antibiotics TLS ... low Ca - q8 h TLS ... Treat underlying cause ... ) - Symptoms: CNS ... ) - Symptoms: CNS
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