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diagnosis hematology differential treatment causes chronic cll erythematosus lupus lymphocytic sle systemic activation acute agglutinin algorithm anemia autoimmune behcet cerebritis
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
extramedullary disease ... involvement • 30%: CNS ... : CNS manifestations ... • Tumor lysis syndrome ... #Hematology #Oncology
Treatment Schema for Standard-Risk Acute Lymphoblastic Leukemia Induction: • Vincristine, Steroid (dexamethasone), L-Asparaginase, Intrathecal (IT) methotrexate Consolidation
Consolidation & CNS ... Cytarabine #ALL ... Treatment #timeline #oncology ... #pediatrics #peds ... #management
Tumor Lysis Syndrome An acute, life-threatening condition that appears within 7 days of starting cytotoxic therapies in
Tumor Lysis Syndrome ... lymphoma & Acute leukemia ... (both ALL and AML ... #TLS #oncology ... #management #UricAcid
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
cells can indicate disease ... • Richter’s Syndrome ... • Sezary syndrome ... diagnosis #workup #oncology ... #hematology
Behçet's Syndrome Systemic disease associated with inflammation of multiple organs, small-vessel vasculitis and large-vessel vasculopathy Epidemiology: • Young
basal ganglia, CNS ... meningitis), MCC CNS ... tears, Ischemia, Leukemia ... collaboration • CNS ... #diagnosis #management
Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
Lymphoma (HCV) • CLL ... • Heavy Chain disease ... Scleromyxedema (CNS ... Sneddon-Wilkinson disease ... Differential #Diagnosis #Oncology
Hypoxemia / Hypoxia - Rapid Response Management Algorithm Stridor - Upper airway pathology: • Anaphylaxis • Foreign
Rapid Response Management ... asthma • Pleural disease ... Hypoventilation: • CNS ... e.g., GBS, MG, ALS ... differential #Diagnosis #Management
CNS Manifestations of Systemic Lupus Erythematosus (SLE) Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
CNS Manifestations ... Demyelinating Syndrome ... Cerebrovascular Disease ... Erythematosus #SLE #CNS ... #neurology #rheumatology
Multiple Cranial Neuropathies - High Yield Differential Diagnosis • Intrinsic brainstem process • Compressive brainstem process
Neurosarcoidosis • CNS ... Lyme Disease, TB ... Miller Fisher Syndrome ... variant-GBS • Bulbar ALS
Chronic Lymphocytic Leukemia (CLL) - Summary Overview: • Most common leukemia in adults • Disorder of
(CLL) - Summary ... • Most common leukemia ... chemotherapy for low-risk disease ... #oncology #hematology ... hemeonc #diagnosis #management
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