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diagnosis anesthesia anesthesiology intraoperative workup lupus treatment hematology differential syndrome druginduced erythematosus hemophagocytic hlh lymphohistiocytosis neurology signs summary symptoms systemic
CNS Manifestations of Systemic Lupus Erythematosus (SLE) Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
Erythematosus (SLE ... autoantibodies that will cause ... Erythematosus #SLE ... #rheumatology # ... cerebritis #diagnosis #management
Hydroxychloroquine Serum Measurement in SLE • Terminal elimination half-life = 40 days ([HCQI reflects long-term intake)
Measurement in SLE ... • Special cases ... #Measurement #SLE ... #rheumatology # ... levels #lupus #management
Systemic Lupus Erythematosus (SLE) - Diagnosis and Management Summary • Epidemiology: 10-180/100,000, Typically Age 20-40, F:M
Diagnosis and Management ... Positive in 60-80% of cases ... Usual therapeutic management ... Erythematosus #Diagnosis #Management ... #Summary #rheumatology
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
Induced Lupus vs SLE ... Discontinuation of causal ... Usual therapeutic management ... comparison #table #rheumatology ... #diagnosis #management
Behçet's Syndrome Systemic disease associated with inflammation of multiple organs, small-vessel vasculitis and large-vessel vasculopathy Epidemiology: • Young
Oral aphthae : SLE ... • Arthritis: SLE ... inhibitors • Uveitis- Ophthalmology ... Syndrome #diagnosis #management ... signs #symptoms #rheumatology
Cardiac Arrest - Guidelines for Crises in Anaesthesia The probable cause is one or more of: something
The probable cause ... • See Boxes B ... CardiacArrest #Checklist ... Intraoperative #Checklist ... #Diagnosis #Management
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
Autoimmune diseases: SLE ... Drugs, Unknown cause ... 100 mg/m2) : in case ... Lymphohistiocytosis #diagnosis #management ... treatment #summary #rheumatology
Malignant Hyperthermia Crisis - Guidelines for Crises in Anaesthesia Unexplained increase in ETCO2 AND tachycardia AND increased
Guidelines for Crises ... other, more common causes ... complications (see ... Intraoperative #Checklist ... #Diagnosis #Management
Intraoperative Hypertension - Guidelines for Crises in Anaesthesia Hypertension is most commonly due to inappropriate depth of
hypercarbia as causes ... be diagnostic – see ... syndrome) • Medical causes ... Intraoperative #Checklist ... #Diagnosis #Management
Can’t Intubate, Can’t Oxygenate (CICO) - Guidelines for Crises in Anaesthesia This is the last resort when
Guidelines for Crises ... optimal airway management ... Access – FoNA (see ... Intraoperative #Checklist ... #Diagnosis #Management
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