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management differential autoantibodies erythematosus lupus neurology systemic treatment antinuclear disease hematology infectiousdiseases myopathy signs sle symptoms anemia arthritis associations autoimmune
Myositis Specific Antibodies (MSAs) Dermatomyositis: MDA5, TIF1y, NXP2, Mi-2, SAE Anti-Synthetase Syndrome: Jo-1, PL7, PL12, EJ, OJ Immune Mediated
Myositis Specific ... Inclusion Body Myositis ... MithuRheum #Myositis ... #diagnosis #rheumatology ... #table
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
Cold Sensitive Antibodies ... Donath-Landsteiner Antibodies ... Syndrome (CAS): ... Viral Infection Clinical ... hemolytic #anemia #hematology
Autoantibodies in Rheumatology • Lupus (SLE): ANA (anti-nuclear antibody), dsDNA (double-stranded DNA), Anti-Smith, Anti-Ro (SSA) and
• Lupus (SLE): ANA ... others (RNP, aPL antibodies ... Peptide (CCP) • Myositis ... #diagnosis #associations ... #table
Neuromyelitis Optica (NMO) - Clinical Manifestations • Optic neuritis: Reduced visual acuity, ranging from mild to
Optica (NMO) - Clinical ... • Transverse myelitis ... pain • Extra-CNS ... positive NMO only): Myositis ... Manifestations #diagnosis
Inflammatory Myopathies Dermatomyositis • Onset: Subacute • Pattern: Proximal • CK: Up to 50X ULN • Autoantibodies:
Necrotizing Autoimmune Myositis ... Inclusion Body Myositis ... Pattern: Proximal and ... #comparison #rheumatology ... #table
Transverse Myelitis Overview Focal inflammatory disorder of the spinal cord resulting in rapid onset of weakness, sensory
Transverse Myelitis ... of Transverse Myelitis ... that results in CNS ... - Clinical Presentation ... Antiamphiphysin antibodies
Systemic Lupus Erythematosus - Diagnosis Manifestations: - Arthritis 69% - Malar rash 40% - Fever 36% -
Erythematosus - Diagnosis ... anemia 4% - Myositis ... SLE-Related Auto-Antibodies ... : - ANA 95-100% ... #differential #rheumatology
Antinuclear Antibodies (ANA) ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
Antinuclear Antibodies ... Antibody refers to antibodies ... likely it will be clinically ... Sjögren Syndrome, Myositis ... #rheumatology #diagnosis
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
salivary ducts Clinical ... nervous system (CNS ... neuropathy, transverse myelitis ... • 8%-27% for CNS ... Sjogrens #Syndrome #Rheumatology
Statin Induced Muscle Toxicity - Summary Clinical Presentation: • Elevations of serum creatine kinase with proximal myalgia
Toxicity - Summary Clinical ... • Myalgia • Myositis ... inclusion body myositis ... myopathy (IMNM) → Antibodies ... IU/I • SAMS clinical
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