31 results
Myositis Specific Antibodies (MSAs)

Dermatomyositis: MDA5, TIF1y, NXP2, Mi-2, SAE
Anti-Synthetase Syndrome: Jo-1, PL7, PL12, EJ, OJ
Immune Mediated
Myositis Specific ... Inclusion Body Myositis ... Antibodies #MSAs #clinical ... #diagnosis #rheumatology ... #table
Inflammatory Myopathies
Dermatomyositis
 • Onset: Subacute
 • Pattern: Proximal
 • CK: Up to 50X ULN
 • Autoantibodies:
heliotrope, shawl sign ... Inflammatory #Myopathies #differential ... #diagnosis #comparison ... #rheumatology # ... table
Neuromyelitis Optica (NMO) - Clinical Manifestations
 • Optic neuritis: Reduced visual acuity, ranging from mild to
Optica (NMO) - Clinical ... • Transverse myelitis ... pain • Extra-CNS ... Manifestations #diagnosis ... neurology #symptoms #signs
Weakness - Differential Diagnosis Framework

Approach To Weakness:
 • Non-neuromuscular disorder (Cardiac, pulmonary etc)
 • CNS ->
Weakness - Differential ... Diagnosis Framework ... pulmonary etc) • CNS ... Lack of UMN/LMN signs ... #Diagnosis #neurology
Blood Disorders - Markers and Differential Diagnosis Algorithm 
Acute
 • Myloid (AML) - CD13, CD33, CD34,
- Markers and Differential ... Diagnosis Algorithm ... Lymphadenopathy, CNS ... Blood #Disorders #hematology ... #Diagnosis #Algorithm
Nail diseases and disorders.
 - Spoon Nails (Koilonychia)
 - Pitting of Nails
 - Beau's Lines
 -
white spots) #Diagnosis ... Fingernail #Disorders #Differential ... #Leukonychia #Table ... #Clinical #PhysicalExam
Systemic Lupus Erythematosus - Diagnosis
Manifestations:
 - Arthritis 69%
 - Malar rash 40%
 - Fever 36%
 -
anemia 4% - Myositis ... (aPL) 30-45% Differential ... autoantibodies #signs ... symptoms #mimickers #differential ... #rheumatology
Transverse Myelitis Overview

Focal inflammatory disorder of the spinal cord resulting in rapid onset of weakness, sensory
that results in CNS ... - Clinical Presentation ... • Bilateral signs ... Diagnosis: • ... #neurology #differential
Faget's Sign & Liebermeister's Rule
Pulse-Temperature Dissociation
EVERY 1 F RISE IN TEMPERATURE -> HR INCREASES 8-10 BPM
INFECTIOUS
Faget's Sign & Liebermeister's ... Beta Blockers • CNS ... • Drug Fever CLINICAL ... #Dissociation #diagnosis ... #differential #
Differential diagnosis of Langerhans cell histiocytosis.
Nodular LCH:
- Sarcoidosis: perilymphatic distribution.
- Metastases: random distribution.
Cystic LCH:
- LAM: round
Differential diagnosis ... : 'signet ring sign ... central dot. - LIP #Clinical ... #Diagnosis #Radiology ... #Comparison #Table