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differential rheumatology neurology management vasculitis algorithm autoimmune cauda caudaequina causes classification compylobacterjejuni cord disorders equina erythematosus extremity flaccidpalsy gbs guillainbarresyndrome
Transverse Myelitis Overview Focal inflammatory disorder of the spinal cord resulting in rapid onset of weakness, sensory
Transverse Myelitis ... of Transverse Myelitis ... that results in CNS ... Transverse Myelitis ... negative, MOG-IgG test
Cauda Equina Syndrome Overview Cauda Equina Syndrome: • Prevalence: 1:33,000-100,000 ppl/yr • Incidence: 1.5-3.4 million ppl/yr •
(CES) is usually ... • Transverse myelitis ... lumbar stenosis • Vascular ... • Provocative Tests ... absent anal wink test
Leg Pain - Differential Diagnosis Framework Bone/Joint Causes of Leg Pain: • Fracture • Arthritis • Gout/pseudogout
- Differential Diagnosis ... Sciatica • Tarsal tunnel ... • Myositis/pyomyositis ... #lower #extremity ... #msk #physicalexam
Guillain–Barré syndrome (GBS) (aka: Landry–Guillain–Barré–Strohl syndrome:  Most common cause of acute flaccid paralysis  Rapidly progressive ascending paralysis & areflexia  Autonomic
Guillain–Barré syndrome ... moves rapidly from lower ... Differential diagnosis ... Multiple Sclerosis: CNS ...  Transverse myelitis
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
Differential Diagnosis ... (hypertension, lower ... and CNS • Headache ... • Transverse Myelitis ... Erythematosus #Diagnosis
Spinal Cord Disorders - Differential Diagnosis Framework Spinal cord neurological lesion: Clinical findings: • Symptoms and signs below
- Differential Diagnosis ... - Transverse myelitis ... Vascular/Blockage ... Behcet disease - SLE ... MCTD, Sjogren syndrome
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
overlaps with RA, SLE ... Diagnosis: • Dry ... neuropathy, transverse myelitis ... • 8%-27% for CNS ... phenomenon (16%) MSK
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
diseases, such as SLE ... pulse deficits vascular ... the upper and lower ... Palpable purpura (lower ... chorioretinitis, CNS
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
- Differential Diagnosis ... the upper and lower ... and bullous or vesicular ... retinopathy Lab Tests ... vasculitis, and SLE
Autoimmune Myositis - Differential Diagnosis Framework Inflammatory Myopathies: Commonly symmetric proximal muscle weakness, no substantial muscle pain
Autoimmune Myositis ... Tests: • Measure ... INCLUSION BODY MYOSITIS ... lung disease • Myositis ... #Autoimmune #Myositis
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