15 results
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes
Intravascular Hemolysis:
 • Mechanical Trauma (Microangiopathic hemolytic anemia):
) - HELLP syndrome ... uremic syndrome ... usually IgG) (e.g. lupus ... #differential # ... diagnosis #hematology
Causes of Purpura or Easy Bruising in Children

Platelet count reduced, i.e. thrombocytopenia
 - Increased platelet destruction
SLE (systemic lupus ... uraemic syndrome ... Kasabach—Merritt syndrome ... Wiskott—Aldrich syndrome ... Bernard—Soulier syndrome
Purpura - Differential Diagnosis Framework

Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
Purpura - Differential ... DIC/TTP/HUS - Hemolytic ... Kasabach-Merritt syndrome ... Gardner-Diamond syndrome ... #Diagnosis #hematology
Cold Agglutinin Disease

3 Types of Cold Sensitive Antibodies:
  1. Cold Agglutinins (CAD)
  2. Donath-Landsteiner
lymphoproliferative disorder ... Agglutinin Syndrome ... Diagnosis: • hemolytic ... younger pts) Differential ... #anemia #hematology
CNS Manifestations of Systemic Lupus Erythematosus (SLE)

Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
Demyelinating Syndrome ... , Seizure disorders ... Disease, PRES Pathophysiology ... autoantibodies that will cause ... #management #treatment
Leukostasis vs Tumor Lysis Syndrome
Leukostasis:
 • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
vs Tumor Lysis Syndrome ... hyperviscosity syndrome ... rasburicase Tumor Lysis Syndrome ... #Tumor #Lysis #Syndrome ... #management #hematology
Myelodysplastic Syndromes (MDS)

What?
Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
Myelodysplastic Syndromes ... Myelodysplastic syndromes ... age 70 years Symptoms ... blood count with differential ... #diagnosis #hematology
Complications after Bariatric Surgery
Post Bariatric Intestinal Failure:
 • Severe protein malnutrition after bariatric surgery
 • More
Consider refeeding syndrome ... deficiencies) Dumping Syndrome ... causes increased ... Gastroenterology and Hepatology ... #differential
TAFRO

TAFRO syndrome was first described in 2010, standing for:
- Thrombocytopenia
- Anasarca
- Fever
- Reticulin fibrosis
- Organomegaly

TAFRO syndrome
TAFRO TAFRO syndrome ... including systemic lupus ... syndrome (SFTS) ... and the systemic symptoms ... #management #rheumatology
Differentiation Syndrome in APML
Epidemiology:
 • Incidence: common in APL (2-48% depending on the study)
 • Triggers:
Differentiation Syndrome ... Pathophysiology ... : >3 symptoms, or ... Differentiation #Syndrome ... #management #hematology