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diagnosis management dermatology rheumatology chronic differential hemeonc lymphocytic syndrome antinxp2 antinxp2dm ascites classification clinical coagulation dermatomyositis dic disseminated emergencies erythematosus
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
extramedullary disease ... -> AML: Blast crises ... violaceous, nontender cutaneous ... lymphoid organs When Cancer ... #Hematology #Oncology
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
- Summary Cancer ... cells can indicate disease ... microglobulin Treatment ... diagnosis #workup #oncology ... #hematology
Chronic Lymphocytic Leukemia (CLL) - Summary Overview: • Most common leukemia in adults • Disorder of
(CLL) - Summary ... Waiting" →several RCTs ... chemotherapy for low-risk disease ... uw_IMresidency #CLL ... #oncology #hematology
Sweet Syndrome Acute febrile neutrophilic dermatosis (Sweets Syndrome) is a skin condition characterized by fever and inflamed
with systemic disease ... Most common extra cutaneous ... Causes: - Idiopathic ... Treatment: - Systemic ... #oncology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
Malignancy (e.g. hematologic ... involve PNS and CNS ... Hodgkin lymphoma and leukemia ... • Lung cancer ... • Cervical cancer
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
promyelocytic leukemia ... involvement (2%) Cutaneous ... • Severe Liver Disease ... Treat primary cause ... #hematology
Summary of Oncologic Emergencies Neutropenic fever: - Fever + ANC < 500 → start cefepime ± vancomycin (if
Summary of Oncologic ... syndrome): - Hematologic ... Treat underlying cause ... Usually myeloid leukemias ... ± tocilizumab; call
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
Chronic Myelogenous Leukemia ... Leukemia • Idiopathic ... Myeloproliferative Disease ... Syndromes #diagnosis #hematology ... #oncology
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
Hypocomplementemia • Can cause ... skin (xerosis) • Cutaneous ... Nephrogenic DI Hematologic ... lymphoma • B cell ... Adenocarcinoma Treatment
Common Malignancies That Cause Ascites The most common malignancies causing ascites are ovarian cancer, pancreatic cancer, gastric
particularly notable for its ... - Signet ring cell ... - Advanced disease ... Differential #Diagnosis #Hepatology ... #oncology
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