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diagnosis rheumatology differential management dermatology sle systemic causes ana antinuclear classification vasculitis algorithm antibodies neurology signs symptoms alopecia hairloss manifestations
ANA Patterns and Associated Rheumatic Diseases: • Homogeneous: Systemic lupus erythematosus (SLE), Mixed connective tissue disease
Associated Rheumatic Diseases ... erythematosus ( ... connective tissue disease ... SLE), Sjogren's Syndrome ... ANA #patterns #rheumatology
CNS Manifestations of Systemic Lupus Erythematosus (SLE) Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
Erythematosus ( ... Demyelinating Syndrome ... Cerebrovascular Disease ... #Erythematosus ... #rheumatology #
BEE Syndromes - Immune-mediated conditions affecting the brain, eye, and ear Visual or auditory symptoms in conjunction
nervous system (CNS ... and less common diseases ... diagnosis and treatment ... • Systemic lupus ... erythematosus
Systemic Lupus Erythematosus - Summary Antinuclear (ANA) - 95% - Initial screening test Anti-dsDNA - 50% • Associated
Systemic Lupus Erythematosus ... block • Sjogren syndrome ... Treatment: • ... #Systemic #Lupus ... #Erythematosus
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
Malignancy (e.g. hematologic ... lymphoma • Evans' syndrome ... Shrinking lung syndrome ... involve PNS and CNS ... vein thrombosis Hematologic
Skin Conditions Associated with Joint Pain Rash • Human parvovirus B19 infection Malar rash • SLE • Human parvovirus B19 infection •
infection • Lyme disease ... Vesicopustule on erythematous ... Antiphospholipid-antibody syndrome ... lesions • Discoid lupus ... erythematosus
Antinuclear Antibodies (ANA) ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
erythematosus ( ... erythematosus ( ... SLE), Sjogren's Syndrome ... Arthritis, Sjögren Syndrome ... ANA #patterns #rheumatology
Pancytopenia - Differential Diagnosis Congenital Diseases: • GATA2 deficiency • Fanconi’s anemia • Wiskott-Aldrich syndrome • Ribosomopathy or telomeropathy Cancer: • Leukemia • Lymphoma Inflammatory
Congenital Diseases ... Wiskott-Aldrich syndrome ... : • Systemic lupus ... erythematosus ... Differential #Diagnosis #Hematology
Classification of Vasculitis Vasculitis of large vessels - Arteritis temporalis (giant-cell arteritis) - Takayasu
Churg-Strauss syndrome ... - systemic lupus ... erythematosus ... - Sjögren syndrome ... Vessels #Diagnosis #Rheumatology
Mucous Membrane Disorder - Differential Diagnosis Algorithm Erosions/Ulcers/Blisters - Primary Dermatologic Diseases •
Stevens-Johnson Syndrome ... • Systemic lupus ... erythematosus ... • Behcet's syndrome ... MucousMembranes #dermatology
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