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Thrombotic Microangiopathies In Systemic Lupus Erythematosus

Dr. Laurent ARNAUD @Lupusreference

#TMAs #Thrombotic #Microangiopathies #Systemic #Lupus #Erythematosus #SLE #hematology
Thrombotic Microangiopathies ... Lupusreference #TMAs #Thrombotic ... Erythematosus #SLE #hematology ... #rheumatology #
Thrombotic Microangiopathy (TMA) - Diagnosis and Management Algorithm

#Thrombotic #Microangiopathy #TMA #Diagnosis #Management #Algorithm #hematology
Thrombotic Microangiopathy ... Algorithm #Thrombotic ... Management #Algorithm #hematology
Thrombotic Microangiopathies - Primary Thrombotic Microangiopathy (TMA) - Differential Diagnosis Table

 • Thrombotic Thrombocytopenic Purpura (TTP)
Thrombotic Microangiopathies ... - Primary Thrombotic ... Diagnosis Table • Thrombotic ... MatthewHoMD #Thrombotic ... Microangiopathy #TMA #hematology
Treatment of Thrombotic Thrombocytopenic Purpura (TTP)
Diagnosis of TTP:
 • Rare and severe, ADAMTS13 deficiency
 • Autoimmune
Treatment of Thrombotic ... from other TMA: Thrombotic ... Cauchois #TTP Thrombotic ... management #treatment #rheumatology ... #hematology
Stroke - Differential Diagnosis Algorithm and Management
Hemorrhagic:
 • Intracerebral: HTN, Cerebral Amyloid Angiopathy, Trauma, Bleeding Diathesis,
Cerebral Venous Thrombosis ... hemorrhage Ischemic: • Thrombotic ... SCVMCMed #Stroke #CVA
Thrombotic Microangiopathy - TTP VS HUS

Big picture points : Often hard to differentiate the two entities,
Thrombotic Microangiopathy ... testing for TTP #Thrombotic ... Diagnosis #Table #Hematology
Differential diagnosis of schistocytes / fragmentation hemolysis:
 • Thrombotic microangiopathies (TMA)
    - TTP
hemolysis: • Thrombotic ... - Drug-induced thrombotic ... differential #diagnosis #hematology
Approach to Thrombotic Microangiopathy (TMA) - Differential Diagnosis and Management Algorithm

Suspected TMA: Unexplained thrombocytopenia + MAHA
Approach to Thrombotic ... MatthewHoMD #Thrombotic ... Management #Algorithm #hematology
Algorithm for workup of thrombocytopenia based on observation of the peripheral blood film. 
TTP/HUS indicates thrombotic
/HUS indicates thrombotic ... thrombocytopenia, Hematology
Pathophysiology of Hypocomplementemic Urticarial Vasculitis

C1q/anti-C1q antibiody ->
Immune Complex Formation - Complement Pathway Activation (C3a and C5a)
Pathophysiology ... Pathway Activation (C3a ... and C5a) -> Anaphylatoxins ... Vasculitis #HUV #Pathophysiology ... #Rheumatology