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diagnosis symptoms signs management differential cardiology endocrinology nephrology pharmacology syndrome algorithm pulmonary causes clinical infectiousdiseases complications hepatology msk lifecycle ophthalmology
Pathophysiology of Tumor Lysis Syndrome (TLS) Tumor Cell Lysis -> Release of DNA • Purines -> Hypoxanthine /
Pathophysiology ... Phosphorus -> Ca-Phos ... urine pH) • Ca-Phos ... Syndrome #TLS #Pathophysiology
Vitamin D Metabolism Fat-soluble vitamin Sources: dermal synthesis and food (dairy products, fish) Active form: calcitriol (1,25-OH Vitamin D) Main
absorption of Ca ... endocrinology #pathophysiology
Tumor Lysis Syndrome (TLS) Pathophysiology Culprits: ALL, Burkitt, SCLC Cells all die at once = ↑Phos, ↓Ca, ↑K,
Syndrome (TLS) Pathophysiology ... once = ↑Phos, ↓Ca ... Arrhythmias ↑Phos -> ↓Ca ... Syndrome #TLS #Pathophysiology
Gitelman Syndrome Pathophysiology Gitelman Syndrome is a rare autosomal recessive salt-losing tubulopathy with a prevalence of 1-
Gitelman Syndrome Pathophysiology ... Contraction → ↑ Renin ↑ Ca ... Gitelman #Syndrome #Pathophysiology
Antiarrhythmics - Vaughan Williams Classification: CLASS 1 - Sodium Channel Blockers: • MOA: Block fast Na+ channels
activation (↓ cAMP and Ca ... receptors, and Ca ... MOA: Block slow Ca ... channels to prevent Ca ... Classification #Classes #pathophysiology
Antiarrhythmics Pharmacology Summary Cardiac Conduction Phases: Phase 0 - Ventricular Depolarization: • Na+ channels open leading to a
Plateau Phase • Ca ... leading to slow Ca ... receptors, and Ca ... MOA: Block slow Ca ... Classification #Classes #pathophysiology
Digoxin Pharmacology and Pathophysiology 1) Na/K ATPase Pump - Digoxin works by directly binding to and inhibiting
Pharmacology and Pathophysiology ... increase. 2) The Na/Ca ... increase, the Na+2/Ca ... #Pharmacology #Pathophysiology
Refeeding Syndrome: Pathogenesis and clinical findings Patients at Risk of Refeeding Syndrome: - Little or no nutritional
Decr Serum K, Mg, Ca ... Syndrome #diagnosis #pathophysiology
Bone resorption and the relationship between osteoblasts and osteoclasts. RANK is expressed on the osteoclasts,
= cathepsin K, CA ... #Pathophysiology
Calcium Electrolyte Repletion Always correct Ca for albumin before deciding if it is abnormal
Always correct Ca ... Corrected Ca ... = Measured Ca +
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