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diagnosis management hematology anesthesia anesthesiology differential intraoperative causes oncology hemolytic cardiac clinical crisis macrocytic pancytopenia pathology smear airway atlas blood
Blood Disorders - Markers and Differential Diagnosis Algorithm Acute • Myloid (AML) - CD13, CD33, CD34,
Blood Disorders ... Differential Diagnosis Algorithm ... Pelger-Huet, Macrocytic anemia ... or λ), Smudge Cells ... Differential #Diagnosis #Algorithm
Peripheral Blood Smear Analysis Hypochromia Megaloblastic Anemia Schistocytes: Microangiopathic hemolytic anemia (e.g. DIC, TTP, HUS) Microspherocytes: Autoimmune hemolytic anemia Sickled red
Megaloblastic Anemia ... Sickled red cells ... : Sickle cell disease ... Bite cells: G6PD ... Analysis #hematology #microscopy
Hemolysis - Diagnostic Algorithm and Causes Increased red cell production: • Increased Reticulocytosis/polychromasia • Erythroid
Hemolysis - Diagnostic Algorithm ... Increased red cell ... Increased red cell ... Hemolysis #Hemolytic #Anemia ... #Causes #Workup
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
are a group of disorders ... formed or don’t work ... Neutropenia • Platelet Disorders ... abnormal under a microscope ... Workup: • Complete
Atlas of Urine Microscopy Findings • Epithelial cells - Normal • Renal tubular cells - Acute
• Epithelial cells ... Renal tubular cells ... Nondysmorphic red - cells ... Dysmorphic red cells ... indicate metabolic disorders
Anemia - Underproduction Diagnostic Algorithm - Iron deficiency anemia - Anemia of chronic inflammation - Anemia
Anemia - Underproduction ... Diagnostic Algorithm ... Probable bone marrow disorder ... Underproduction #Algorithm ... #differential #workup
Hemolytic Anemia - Differential Diagnosis Algorithm Hereditary: • Peripheral blood smear + DAT + further History •
Differential Diagnosis Algorithm ... History • Bite cells ... Deficiency • Sickle cells ... DAT (-) → Sickle Cell ... Differential #Diagnosis #Algorithm
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
cells can infiltrate ... or basket cells ... lymphoproliferative disorders ... • Neutropenia, anemia ... Leukemia #diagnosis #workup
Red Blood Cell (RBC) Morphology Microcytic RBC: Pyridoxine deficiency, Thalassemia, Iron deficiency anemia, Chronic disease anemia (sometimes),
Red Blood Cell ( ... Iron deficiency anemia ... Chronic disease anemia ... Unstable hemoglobin disorders ... diagnosis #hematology #microscopy
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
Hemolytic Anemia ... • Sickle cells ... Consider sickle cell ... Consider RBC membrane disorder ... #workup #hematology
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