16 results
My Patient with Infective Endocarditis (IE) Has Negative Blood Cultures
 - Did they receive antibiotics prior
therapy - Number one cause ... of culture negative ... patient a surgical candidate ... #Diagnosis #Management ... #Algorithm
Microorganisms Responsible for Infective Endocarditis

Native valves:
 - Streptococcus viridans 
 - Enterococci 
 - Other streptococci
Responsible for Infective ... Endocarditis ... bacilli - Fungi (Candida ... negative #Infective ... Bacteria #Pathogens #Diagnosis
Endocarditis Algorithm - Infective vs Noninfective Causes
Noninfective:
 • Malignancy
 • Autoimmune disease
 • Systemic infection
Native Valve
Endocarditis Algorithm ... Noninfective Causes ... • HACEK • Culture-negative ... #Algorithm #Infective ... #Differential #Diagnosis
Causes of blood culture negative infective endocarditis

Bartonella spp, Brucella spp, Coxiella burnetii, Chlamydia spp, Tropheryma whipplei,
culture negative ... infective endocarditis ... (Aspergillus, Candida ... #causes #culture ... #negative #Endocarditis
Causes of Dysuria - Differential Diagnosis Algorithm
Pyuria - Leukocytes on Dipstick/Microscopy
 - Bacteriuria & Hematuria -
- Differential Diagnosis ... Algorithm Pyuria ... Urinary Tract Infection ... Hematuria - Dipstick negative ... #Algorithm #Causes
Blood Culture-Negative Infective Endocarditis (BCNIE)
Definition: No etiology found after 3 separate blood cultures remain negative for
Blood Culture-Negative ... Infective Endocarditis ... but important causes ... (Aspergillus, Candida ... #Infective #Endocarditis
Differentiating NBTE from Infective Endocarditis
No pathognomonic signs/symptoms or echo features that are specific to NBTE, and
Differentiating NBTE from Infective ... specific to NBTE, and diagnosis ... is required for diagnosis ... Frequent false-negative ... in up to 30% of cases
Acute Kidney Injury - AKI Workup Algorithm and Differential Diagnosis
Baseline Investigations: full blood count with differential,
Acute Kidney Injury ... - AKI Workup Algorithm ... and Differential Diagnosis ... dipstick, urine microscopy ... osmolarity If cause
Endocarditis Summary

Who?
Infectious:
• Pre-existing valvular disease
• Prosthetic valve
• Congenital heart disease
• IV substance use
• IV catheter
• Recent
Hypercoagulable (APLAS ... • Coagulase-negative ... Septic Emboli Cause ... Diagnosis? ... Treat underlying cause
Rapidly Progressive Glomerulonephritis (RPGN)
RPGN has three primary pathophysiologic causes differentiated by immunofluorescence

Immune Complex Mediated (granular staining):
pathophysiologic causes ... Cryoglobulinemia, Endocarditis ... • Limited to Kidney ... #differential #diagnosis ... #algorithm #rheumatology