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diagnosis differential microbiology endocarditis fungal infections morphology negative pathology cardiology causes infective yeasts abscess bacteria bloodculture clinical cnie comparison endemic
Causes of blood culture negative infective endocarditis Bartonella spp, Brucella spp, Coxiella burnetii, Chlamydia spp, Tropheryma whipplei,
Causes of blood culture ... Tropheryma whipplei, Fungi ... (Aspergillus, Candida ... #Endocarditis #InfectiousDiseases ... #BCNIE #cardiology
Blood Culture-Negative Infective Endocarditis (BCNIE) Definition: No etiology found after 3 separate blood cultures remain negative for
fastidious bacteria or fungi ... Tropheryma whipplei, Fungi ... (Aspergillus, Candida ... bacteria) and 18S ( fungi ... differential #workup #infectiousdiseases
Microorganisms Responsible for Infective Endocarditis Native valves: - Streptococcus viridans - Enterococci - Other streptococci
Gram-negative bacilli - Fungi ... (Candida, Aspergillus ... Histoplasma) - Culture ... streptococci - Culture ... #Differential #InfectiousDiseases
Transplant Infections Timeline Pre-transplant: • Common bacteria (endogenous): Staphylococci (skin), Gram-negative bacilli (gut) • Viruses: HSV (reactivation) Engraftment:
difficile (gut) • Fungi ... : Candida spp. ... (mucosa), Aspergillus ... : Aspergillus spp ... diagnosis #causes #infectiousdiseases
Morphology and Descriptions of Fungal Infections with Hyphae or Pseudohyphae in Tissues Yeasts with Pseudohyphae: •
Consistent with Candida ... spp. however Aspergillus ... other hyaline fungi ... with dematiaceous fungi ... septations #pathology #atlas
Morphology and Descriptions of Endemic Fungal Infections with Yeasts in Tissues Broad-based budding yeasts: • Description: Broad-based
Cryptococcus, and Aspergillus ... other hyaline fungi ... with dematiaceous fungi ... yeasts #fungal #fungi ... morphology #pathology #atlas
Causes of Culture Negative Abscess - Differential Diagnosis Framework Consider prior antibiotics as a cause of a
Causes of Culture ... of a negative culture ... Scedosporium, endemic fungi ... Kumfer @AnnKumfer #Culture ... Differential #Diagnosis #InfectiousDiseases
Morphology and Descriptions of Endemic Fungal Infections with Yeasts in Tissues Broad-based budding yeasts: • Description: Broad-based
Coccidioides spp, Candida ... Cryptococcus, and Aspergillus ... , Histoplasma, Candida ... pathology #clinical #atlas ... #fungi #microbiology
Important Fungal Stains Mycology Lab: • Calcofluor white - Fluorochrome that binds glucans and chitin in fungal
preparation from culture ... cell response to fungi ... doesn't stain most fungi ... exceptions are Aspergillus ... #microbiology #microscopy
Endocarditis - Overview and Differential Diagnosis Framework Who? Infectious: • Pre-existing valvular disease • Prosthetic valve • Congenital heart disease • IV
Hypercoagulable (APLAS ... 90% of IE cases Culture ... staphylococci Culture ... Tropheryma Whipplei • Aspergillus ... Diagnosis #cardiology #infectiousdiseases
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