10 results
My Patient with Infective Endocarditis (IE) Has Negative Blood Cultures
 - Did they receive antibiotics prior
Negative Blood Cultures ... antibiotics prior to cultures ... Fungal (Histoplasma/Aspergillus ... patient a surgical candidate ... BloodCultures #Diagnosis #Management
Invasive Candidiasis (IC)

Diagnosis:
Culture:
 • Gold standard, but Slow (~2-3 days), 50% sensitivity
 • Blood Sample
 •
Diagnosis: Culture ... Line Targeted Treatment ... Additional management ... #candida #auris ... #treatment
Hematuria in Post-Renal Transplant Patient
Prevalence up to 12% in the postrenal transplant patient
 • Bacterial: Escherichia
Virus • Fungal: Candida ... Cryptococcus Neoformans, Aspergillus ... #blood #urine #management ... #treatment #nephrology
Candidemia Workup and Management - IDSA Guidelines
1) Antibiotics
 • Empiric: Echinocandins (e.g. micafungin) for most patients
Candidemia Workup and Management ... Susceptibilities, Negative Cultures ... IDSA #Guidelines #Management ... #candida #candidiasis ... #treatment #fungal
Endocarditis Summary

Who?
Infectious:
• Pre-existing valvular disease
• Prosthetic valve
• Congenital heart disease
• IV substance use
• IV catheter
• Recent
Hypercoagulable (APLAS ... 90% of IE cases Culture ... Tropheryma Whipplei • Aspergillus ... • Blood cultures ... Endocarditis #diagnosis #management
Endocarditis - Overview and Differential Diagnosis Framework

Who?
Infectious:
• Pre-existing valvular disease
• Prosthetic valve
• Congenital heart disease
• IV
Hypercoagulable (APLAS ... 90% of IE cases Culture ... staphylococci Culture ... Tropheryma Whipplei • Aspergillus ... hematuria, + RF Treatment
Debridement and Management of Prosthetic Joint Infection (PJI)
Duration of symptoms <3 weeks OR  <30 days
Debridement and Management ... expectancy, poor candidacy ... for future surgeries ... Joint #Infection #treatment ... #Debridement #Management
Majocchi’s Granuloma due to Trichophyton rubrum 
This is GMS stain and culture of a skin biopsy
GMS stain and culture ... Treatment: Itraconazole ... Non-dermatophytes: Aspergillus ... Majocchi granuloma Treatment ... clinical #photo #microscopy
Blastomycosis Summary

Pathogen: 
 • Dimorphic fungus - Blastomyces dermatitidis or Blastomyces gilchristii.
 • The fungus lives
in New York and Canada ... Skin tissue 2) Culture ... serum/urine Treatment ... Blastomycosis #diagnosis #management ... #treatment #infectiousdiseases
Mycoses

HISTOPLASMOSIS
• Inhalation of conidia → Yeast → travel to lymph nodes → spread in body
• Bird
• Confirmed by culture ... ASPERGILLOSIS • Aspergillus ... Diagnosis: • Culture ... positive blood cultures ... Fungal #Diagnosis #Management