23 results
Management of Immune Checkpoint Inhibitor (ICI) Induced Cardiotoxicity
Problem - Immune checkpoint inhibitors (ICIs) are associated with
Management of Immune Checkpoint ... (ICI) Induced Cardiotoxicity ... Problem - Immune checkpoint ... ✖ Cardiotoxicity ... as indicated #Checkpoint
Immune-related adverse events (irAE) of  immune checkpoint inhibitors (ICI) 

- By Antoine Briantais 
Dr. Benjamin
irAE) of immune checkpoint
The Cell Cycle
The cell cycle is the series of tightly regulated steps that controls cell growth
through the G1/S checkpoint ... /S, S/G2, G2/M checkpoints ... the cell cycle checkpoints ... proliferation #TF #E2F #checkpoint
Undifferentiated shock - Algorithm for the Evaluation of Hypotension. This process for the evaluation of hypotension
halting at evaluable checkpoints
Chemotherapy Toxicity Bear Mnemonic - Cumulatively Toxic Drugs and their Rescues
 • Asparagine: neurotoxicity
 • Cisplatin:
Dexrozoxane (for cardiotoxicity
Myocarditis 

5 Principles of
Myocarditis:
1. Build clinical suspicion
2. Decide on EMBx
3. Manage acute cardiac injury
4. Manage chronic
anti-metabolite - Immune Checkpoint
Check point inhibitors and Side Effects - Immune-related adverse events (IRAEs)

What are the side effects?
 -
by stopping the checkpoint
Aortitis - Differential Diagnosis Framework
Non-Infectious Aortitis:
 • Vasculitides: Giant Cell Arteritis (GCA), Takayasu's arteritis, Cogan's Syndrome,
Erdheim-Chester), Immune Checkpoint
Pulmonary complications of targeted therapy
-Immune checkpoint inhibitors (e.g. pembrolizumab)
-Pneumonitis is uncommon (~5% of patients) but can
therapy -Immune checkpoint
VITAMINS Mnemonic for Acute / Subacute Peripheral Polyneuropathy

Vascular
Inflammatory: Amyloidosis, vasculitis (often more subacute/chronic)
Toxins: Nitrous oxide, chemo,
oxide, chemo, checkpoint