10 results
Acromegaly - Diagnosis and Management Summary - GrepMed Handbook 

Clinical Presentation: 
 • Classic Acromegaly: frontal
paresthesias (carpal ... Differential Diagnosis ... pseudo-acromegaly, obesity, hypothyroidism ... Diagnosis #Management #Endocrinology ... #Treatment #Pathophysiology
Feedback Loop: Growth Hormone (GH)
Growth Hormone:
 • Liver -> GHR activates JAK-STAT pathway -> Incr IGF1
Growth Hormone (GH ... /Symptoms: • GH ... expansion (e.g. carpal ... #FeedbackLoop #endocrinology ... #pathophysiology
Growth Hormone Excess - Pathogenesis and clinical findings
 • Acromegaly and gigantism share the same pathophysiology
share the same pathophysiology ... GH excess prior ... overgrowth: • Carpal ... signs #symptoms #endocrinology ... #pathophysiology
Algorithmic Approach to Hypothyroidism - Differential Diagnosis and Management Framework

Central Hypothyroidism (Secondary or tertiary) ↓TSH, ↓FT4
Algorithmic Approach to Hypothyroidism ... - Differential ... ↓FT4 • Post-GH ... #Differential # ... Diagnosis #algorithm #endocrinology
Sellar / Pituitary Mass - Differential Diagnosis Algorithm
Adenoma - Primary Anterior Pituitary
 - Secreting
Pituitary Mass - Differential ... Prolactin • GH ... Hypothyroidism) ... SellarMass #Pituitary #Differential ... Diagnosis #Algorithm #endocrinology
Tall Stature - Differential Diagnosis Algorithm

Normal Growth (BA=CA)
 • Familial Tall Stature
 • XYY Syndrome
Obese BMI
Tall Stature - Differential ... Puberty Onset • GH ... Excess • Hyperthyroidism ... #TallStature #Differential ... Diagnosis #Algorithm #endocrinology
Short Stature - Differential Diagnosis Algorithm
Normal Variant, Normal Puberty Onset (BA = CA)
 • Familial Short
Short Stature - Differential ... Cushing's Disease • GH ... Dwarfism) • Hypothyroidism ... Panhypopituitarism Treatment ... Diagnosis #Algorithm #endocrinology
Hyperthyroidism Overview

Clinical Manifestation of Hyperthyroidism:
 • Fatigue
 • Weight loss
 • Heat intolerance
 • Depression, nervousness
Hyperthyroidism ... ↑ AST/ALT • Treatment ... tenderness Treatment ... causes #diagnosis #differential ... #endocrinology
Pituitary Mass Effects - Pathogenesis and Clinical Findings
 • Pituitary turnors are almost always a benign
adenomas that require treatment ... following order; GH ... #SideEffects #endocrinology ... mnemonic #GLFTAP #pathophysiology
Rhabdomyolysis - Differential Diagnosis and Management Summary

Trauma:
 • Immobilization, Crush iniury, Compartment syndrome, Electrical injury
Exertional:
 •
Rhabdomyolysis - Differential ... Endocrine (Hypo/Hyperthyroidism ... Dermatomyositis) AKI - Pathophysiology ... oxidative iniury Treatment ... Summary #causes #treatment