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diagnosis symptoms causes differential hypothyroid pituitary acromegaly algorithm excess features feedbackloop glftap macroadenoma management masseffects mnemonic myopathy overproduction paralysis pediatrics
Feedback Loop: Growth Hormone (GH) Growth Hormone: • Liver -> GHR activates JAK-STAT pathway -> Incr IGF1
activates lipolysis Signs ... expansion (e.g. carpal ... metabolic abn #GrowthHormone ... #endocrinology ... #pathophysiology
Growth Hormone Excess - Pathogenesis and clinical findings • Acromegaly and gigantism share the same pathophysiology
overgrowth: • Carpal ... fraction • HTN #GrowthHormone ... #diagnosis #signs ... #symptoms #endocrinology ... #pathophysiology
Acromegaly - Diagnosis and Management Summary - GrepMed Handbook Clinical Presentation: • Classic Acromegaly: frontal
paresthesias (carpal ... malignancy Pathophysiology ... pseudo-acromegaly, obesity, hypothyroidism ... Diagnosis #Management #Endocrinology ... #Treatment #Pathophysiology
Primary Hyperthyroidism - Pathogenesis and Clinical Findings Note: Although rare, gestational diseases can lead to thyrotoxicosis due
Primary Hyperthyroidism ... Secondary hyperthyroidism ... Signs/Symptoms: ... #endocrinology ... #pathophysiology
Hypothyroidism – symptoms and signs. Symptoms: Tiredness/malaise, Weight gain, Anorexia, Cold intolerance, Poor memory, Change in appearance, Depression, Poor libido,
Hypothyroidism – ... symptoms and signs ... , Deafness Signs ... peripheries, Carpal ... #PhysicalExam #Endocrinology
Hyperthyroidism Overview Clinical Manifestation of Hyperthyroidism: • Fatigue • Weight loss • Heat intolerance • Depression, nervousness
Hyperthyroidism ... ↑ AST/ALT • Treatment ... tenderness Treatment ... #differential #endocrinology ... #signs #symptoms
Short Stature - Differential Diagnosis Algorithm Normal Variant, Normal Puberty Onset (BA = CA) • Familial Short
Cushing's Disease • GH ... Dwarfism) • Hypothyroidism ... Panhypopituitarism Treatment ... Diagnosis #Algorithm #endocrinology
Thyrotoxic Periodic Paralysis - Illness Script • Epidemiology: Asian men age 20-30 with hyperthyroidism of any
age 20-30 with hyperthyroidism ... and menses • Pathophysiology ... hormone • Symptoms/signs ... or high T3 • Treatment ... triggers, Treat hyperthyroidism
Hypothyroid Myopathy Very common (up to 80% ) in patients with hypothyroidism Pathophysiology: • T4 deficiency leads to
patients with hypothyroidism ... Pathophysiology ... Hypothyroid #Myopathy #pathophysiology ... #signs #symptoms ... #endocrinology
Pituitary Mass Effects - Pathogenesis and Clinical Findings • Pituitary turnors are almost always a benign
adenomas that require treatment ... following order; GH ... Signs / Symptoms ... #SideEffects #endocrinology ... mnemonic #GLFTAP #pathophysiology
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