20 results
Carpal Tunnel Syndrome: Pathogenesis and clinical findings
 • Dysthesias - Tingling, burning, or painful sensation at
Carpal Tunnel Syndrome ... digits Mild -> Carpal ... #CarpalTunnel #Syndrome ... #pathophysiology ... #msk #overuse
Growth Hormone Excess - Pathogenesis and clinical findings
 • Acromegaly and gigantism share the same pathophysiology
share the same pathophysiology ... overgrowth: • Carpal ... Tunnel Syndrome ... fraction • HTN #GrowthHormone ... Overproduction #diagnosis #signs
Feedback Loop: Growth Hormone (GH)
Growth Hormone:
 • Liver -> GHR activates JAK-STAT pathway -> Incr IGF1
activates lipolysis Signs ... expansion (e.g. carpal ... metabolic abn #GrowthHormone ... endocrinology #pathophysiology
Cubital Tunnel Syndrome: Pathogenesis and clinical findings

 • Paresthesia of 5th and medial half of 4th
Cubital Tunnel Syndrome ... CubitalTunnel #Syndrome ... #Diagnosis #pathophysiology ... #signs #symptoms ... #msk
Hypothyroidism – symptoms and signs.

Symptoms: 
Tiredness/malaise, 
Weight gain,
Anorexia,
Cold intolerance, 
Poor memory,
Change in appearance, 
Depression, 
Poor libido,
– symptoms and signs ... , Deafness Signs ... slowness, Psychosis/dementia ... peripheries, Carpal ... timel syndrome,
Alzheimer’s Disease: Pathogenesis and Clinical Findings
Risk factor for Late Onset Alzheimer's (99% of cases):
 - Increasing
mutations - Down syndrome ... chromosome 21) Signs ... AlzheimersDisease #Dementia ... #pathophysiology ... #geriatrics #diagnosis
Major neurocognitive disorders (MNCD): Diagnosis and workup 

1) Clinical diagnosis Cognitive impairment + loss of autonomy
2)
Aphaso-apraxo-agnosia syndrome ... atrophy Lewy body dementia ... (parkinsonian signs ... Frontotemporal dementia ... Workup #Diagnosis #Geriatrics
Patellofemoral Syndrome - Pathogenesis and clinical findings
 • Anterior Knee Pain with possible symptoms of 'catching'
Patellofemoral Syndrome ... Patellofemoral #Syndrome ... #pathophysiology ... #diagnosis #signs ... #symptoms #msk
Fecal Incontinence - Pathogenesis and Complications
Continence mechanisms are impaired
 • Local neuronal damage
 • External and
irritable bowel syndrome ... (e.g. stroke, dementia ... #Incontinence #geriatrics ... #pathophysiology
Prader-Willi Syndrome: Pathogenesis and clinical findings
 • Maternal uniparental disomy: inheriting 2 copies of maternal chromosome
Prader-Willi Syndrome ... =>Prader-Willi Syndrome ... Signs/Symptoms ... #genetics #pathophysiology ... #peds #pediatrics