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hematology druginduced hemeonc leukemia lupus chronic comparison differentiation emergencies hemophagocytic hlh lymphocytic lymphohistiocytosis lysis mds myelodysplasia myelodysplastic oncologic sjogrens sle
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
, CML, AML, APML ... ALL Symptoms: ... smear: Blasts APML ... ) CLL Symptoms: ... #Oncology #Diagnosis
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
Differentiation Syndrome ... : >3 symptoms, or ... #APML #diagnosis ... #management #hematology ... #oncology
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
with no early symptoms ... Diagnosis: • ... • Richter’s Syndrome ... #workup #oncology ... #hematology
Tumor Lysis Syndrome An acute, life-threatening condition that appears within 7 days of starting cytotoxic therapies in
Tumor Lysis Syndrome ... and AML) and solid ... Walid Malki, MD, MS ... #TLS #oncology ... #management #UricAcid
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
Epidemiology: -10% of all ... Constitutional symptoms ... constitutional symptoms ... comparison #table #rheumatology ... #diagnosis #management
Summary of Oncologic Emergencies Neutropenic fever: - Fever + ANC < 500 → start cefepime ± vancomycin (if
Summary of Oncologic ... ± tocilizumab; call ... : - Seen with AML ... (~20 %) and APL ... #HemeOnc #Diagnosis
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
age 70 years Symptoms ... with isolated del ... progression to AML ... #diagnosis #hematology ... #oncology
Drug Induced Lupus (DIL) • Epidemiology: -10% of all lupus cases, drug-dependent, 4:1 to 1:1 F:M
Epidemiology: -10% of all ... Constitutional symptoms ... #rheumatology # ... diagnosis #treatment ... #management
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
Diagnosis: • Dry ... • Nephrogenic DI ... phenomenon (16%) MSK ... #Rheumatology # ... Diagnosis #Management
Hemophagocytic Lymphohistiocytosis (HLH) High mortality without prompt recognition and management. HLH is a critical diagnostic consideration in
recognition and management ... hyperinflammatory syndrome ... with the HLH syndrome ... Common Signs and Symptoms ... #Management #Hematology
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