Carpal syndrome symptoms diagnosis rheumatology dermatology algorithm table monoclonal mgus

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Suggested algorithm for follow-up of monoclonal gammopathy of undetermined significance (MGUS)
Mayo Clinic Risk Stratification Model. CBC,

Monoclonal Gammopathy of Clinical Significance (MGUS) - Differential Diagnosis

Neurologic-Centered:
(+) Systemic Features: POEMS, AL amyloid, Cryoglobulinemia

Significance (MGUS ... - Differential Diagnosis ... capillary leak syndrome ... • Schnitzler syndrome ... #hematology #oncology

Suggested algorithm for bone marrow biopsy and skeletal imaging in patients with monoclonal gammopathy of undetermined

Paraproteinemias

Entities That Can Feature A Monoclonal Protein/M Component:
• MM
• WM
• MGUS
• MGCS
• MGRS
• Splenic Marginal Zone

Can Feature A Monoclonal ... Amyloidosis and monoclonal ... Paraproteinemias #Hematology ... #Monoclonal #Differential ... #Diagnosis #Oncology

Monoclonal Gammopathy of Undetermined Significance (MGUS) - Summary Framework

Hematologic disorder characterized by the presence of either

Significance (MGUS ... IgM MGUS: • Serum ... constitutional symptoms ... #Significance #hematology ... #diagnosis #oncology

Multiple Myeloma and Monoclonal Gammopathies
C - HyperCalcemia- calcium > 11 mg/dL / >1 mg/dL the ULN
R

Multiple Myeloma and Monoclonal ... if this is is monoclonal ... plasmacytoma, POEMs syndrome ... #Gammopathies #MGUS ... #diagnosis #hematology

Cold Agglutinin Disease

3 Types of Cold Sensitive Antibodies:
1. Cold Agglutinins (CAD)
2. Donath-Landsteiner

Cold Agglutinin Syndrome ... Monoclonal IgM ... significance (MGUS ... hemolytic #anemia #hematology ... #diagnosis

Complications of Monoclonal Gammopathy of Undetermined Significance (MGUS)
Fracture, Osteoporosis
- Increased osteoclast activity and bone resorption

Significance (MGUS ... treatment of infective symptoms ... high-risk situations #MGUS ... Complications #diagnosis ... #hematology

Elevated Globulin - Protein Gap (Total Protein - Albumin > 4)

Work-up of an Elevated Globulin Gap:
•

Gammopathy Include: • MGUS ... changes (POEMS syndrome ... gastric tumors • Hematology ... #differential #diagnosis ... #hematology

Myelodysplastic syndromes current treatment algorithm 2018.

From Blood Cancer Journal, Published 24 May 2018

Myelodysplastic syndromes (MDS) are

Myelodysplastic syndromes ... current treatment algorithm ... Myelodysplastic syndromes ... median age at diagnosis ... #algorithm #hematology

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