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CASTLEMAN DISEASE Disorder of the immune system with excessive production of IL-6 Castleman’s disease is a rare, heterogeneous
CASTLEMAN DISEASE ... • Multicentric Castleman ... asymptomatic, but can cause ... HHV-8-associated cases ... proportion of MCD cases
Causes of Fever of Unknown Origin (FUO) - Differential Diagnosis • Infection: Extrapulmonary tuberculosis, Abscess, Endocarditis,
Causes of Fever ... vasculitis to cause ... Hypothalamic dysfunction, Castleman ... Differential #Diagnosis #causes
Lymphadenopathy - Differential Diagnosis Algorithm Localized: • Cervical: EBV, CMV, HIV, Toxo, TB, Lymphoma, Head /
Miscellaneous: Castleman's ... Diagnosis #Algorithm #Causes
Unicentric Castleman Disease (UCD) vs Multicentric Castleman Disease (MCD) - Comparison Table Unicentric Castleman Disease (UCD): •
Unicentric Castleman ... vs Multicentric Castleman ... Unicentric Castleman ... Multicentric Castleman ... Variable; depends on cause
Multiple Myeloma and Monoclonal Gammopathies C - HyperCalcemia- calcium > 11 mg/dL / >1 mg/dL the ULN R
Causes of false- ... amyloidosis Other causes ... POEMs syndrome, Castleman's
MIAMI Mnemonic for Differential Diagnosis of Lymphadenopathy Malignancies - Kaposi sarcoma, leukemias, lymphomas, metastases, skin neoplasms Infections -
node hyperplasia (Castleman ... sarcoidosis Iatrogenic causes
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 Dermatologic Manifestations of Granulomatosis with Polyangiitis (GPA) Skin involvement in granulomatosis with polyangiitis (GPA) is common and
GPA causes disease ... granulomatosis) • Castleman
Castleman's Disease and Associated Syndromes HYALINE VASCULAR VARIANT • unicentric, HHV8-ve, children and young. • Hyalinized vessels
Castleman's Disease ... associated with Castleman's ... faheema_hasan #Castlemans
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4) Work-up of an Elevated Globulin Gap: •
Causes of Monoclonal ... plasmacytoma • Castleman ... amyloidosis Causes ... anemia • Other causes ... reactants will cause
Pathology - Castleman disease. Mediastinal mass in a younger woman. Histologic Features of Castleman disease, hyaline vascular
Pathology - Castleman ... Histologic Features of Castleman ... @mjcascio #Castleman
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