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management ibd treatment gastroenterology diagnosis ulcerative uc clostridioides 1 5asa bowel cdifficile checkpointinhibitor clostridium clostridiumdifficile crohns differential idsa immune infection
C. Difficile Infection in IBD - IBD Algorithm Background Complications CDI Testing Algorithm CDI Recurrence Dr. Wade Billings @wabillin #Clostridioides #difficile #CDiff
Difficile Infection ... Complications CDI ... CDI Recurrence ... Clostridioides #difficile ... #CDiff #CDifficile
C.diff - Clostridioides Difficile Infection (CDI) - Diagnosis and Management - GrepMed Handbook Clinical Presentation + Progression:
Difficile Infection ... Pseudomembranous colitis ... → Fulminant Colitis ... #Cdiff #Clostridioides ... #Difficile #Clostridium
Persistent UC Symptoms Despite 5-ASA Therapies • Assess for Drug Adherence • Disease Activity Assessment (bloody
Drug Adherence • Disease ... Rule-Out Infection, Cdiff ... Mild Colitis • ... JAK Inhibitor Algorithm ... Treatment #Management #Algorithm
Perianal Crohn's Disease - IBD Algorithm • 5-40% w perianal fistula • ↑ risk if colonic
Perianal Crohn's Disease ... - IBD Algorithm ... risk if colonic CD ... #IBDAlgorithm # ... IBD #Algorithm #
Relapsing Acute Severe Ulcerative Colitis - Management Algorithm Loss of Response: • (Re)consult Colorectal Surgery • Assess
Severe Ulcerative Colitis ... Adherence • Assess Disease ... Diff. & CMV COVID ... Optimize Nutrition • CNI ... Relapsing #Ulcerative #Colitis
IBD Mimics Infectious - Always RULE OUT infection (CMV, C. diff esp.) obtain travel & exposures history:
infection (CMV, C. diff ... Salmonella • Colon: C. difficile ... intestine: Behcet's disease ... , Drug induced colitis ... inflammatroy #bowel #disease
Mild-to-Moderate Ulcerative Colitis - Management Algorithm Curcumin: • Natural phytochemical from turmeric • 2g/day divided in 2-3
Mild-to-Moderate Ulcerative Colitis ... - Management Algorithm ... dosing if liver disease ... formulations • Difficult ... #Ulcerative #Colitis
A proposed management algorithm for CDI in patients with inflammatory bowel disease. *Severe-complicated CDI is defined
proposed management algorithm ... for CDI in patients ... inflammatory bowel disease ... #CDI #CDiff #clostridiumdifficile ... #IBD #Algorithm
Immune Checkpoint Inhibitor-Mediated Colitis Grade of Disease Severity: • G1: Increase < 4 BMs/day over baseline; mild
Inhibitor-Mediated Colitis ... Grade of Disease ... Diff, Stool cx, ... CheckpointInhibitor #Colitis ... diagnosis #management #algorithm
Ulcerative Proctitis Proctitis: • Affects 1/3 patients • Predictors of extension: - Disease
extension: - Disease ... extension • Isolated disease ... Infection (CMV, c-Diff ... rectal prolapse, CD ... diagnosis #management #algorithm
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