31 results
Selective Serotonin Reuptake Inhibitors: Mechanisms and Side Effects
 • Serotonin Syndrome:
   - Autonomic Hyperactivity:
- Cognitive Changes ... Serotonin #Inhibitors #Pathophysiology ... #Pharmacology # ... Psychiatry #Diagnosis #Signs
Common sodium channel blockers which cause QRS widening.

Anticonvulsants: 
 - Carbamazepine 
Antidysrhythmics:  
 - Group
Common sodium channel ... QRS #widening #ECG ... #EKG #Pharmacology ... Toxicology #Diagnosis #Differential
Serotonin-Norepinephrine Reuptake Inhibitors(SNRIs): Mechanisms and Side Effects

Withdrawal: Dizziness, Diarrhea, Insomnia, Nausea, Vomiting
Serotonin Syndrome - Potentially Life
- Cognitive Changes ... SerotoninNorepinephrine #Inhibitors #Pathophysiology ... #Pharmacology # ... Psychiatry #Diagnosis #Signs
Mechanisms of Drug-Induced Hyperkalemia 
 • Direct renin inhibitor (Aliskiren)
 • Renin release inhibition (NSAIDs, Beta-Blockers)
Heparin) • Sodium-channel ... • Increased EC ... #hyperkalemia #differential ... #diagnosis #pathophysiology ... #pharmacology #
Heparin, Fondaparinux, and Novel Oral Anticoagulants - Pathophysiology

Anticoagulation with parenteral (intravenous or subcutaneous) and oral anticoagulants
Anticoagulants - Pathophysiology ... anticoagulant (e.g ... conformational changes ... conformational change ... #Pharmacology #Pathophysiology
Pediatric SVT - Management Algorithm
Identify SVT:
 • HR not variable
 • Abrupt rate changes
 • Infants:
• Abrupt rate changes ... : HR > 180bpm ECG ... Monitors, Pads AP Stable ... Signs of shock or
Approach to Headaches - Differential Diagnosis Algorithm

Red flags (PHANTOMS):
 • Pattern change, progressively worse, papilledema
 •
to Headaches - Differential ... ): • Pattern change ... • Meningeal signs ... Systemic symptoms and signs ... #Headache #Differential
Leukostasis vs Tumor Lysis Syndrome
Leukostasis:
 • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
Leukostasis: • Pathophysiology ... tinnitus, visual changes ... WBC >100k, + lab signs ... Lysis Syndrome: • Pathophysiology ... unless worrisome EKG
Noncardiogenic Pulmonary Edema - Differential Diagnosis Framework

NCPE Pathophysiology:
Noncardiogenic pulmonary edema occurs because of excessive pulmonary capillary
Pulmonary Edema - Differential ... Framework NCPE Pathophysiology ... level <100 pg/ml EKG ... Negative for ischemic changes ... #edema #NCPE #differential
Daliresp (Roflumilast) 
Indication: Reduce risk of COPD exacerbations 
Drug Class: Selective Phosphodiesterase-4 (PDE4) Inhibitor 
GOLD 2019
100 Dosing: 250 mcg ... tablet once daily ... increase to 500 mcg ... have been a few changes ... #Indications #Pharmacology