31 results
Selective Serotonin Reuptake Inhibitors: Mechanisms and Side Effects
 • Serotonin Syndrome:
   - Autonomic Hyperactivity:
- Cognitive Changes ... Serotonin #Inhibitors #Pathophysiology ... #Pharmacology # ... Psychiatry #Diagnosis #Signs
Nephron Pathophysiology - Diuretic Sites of Action
Diuretics
1) Acetazolamide/canagliflozin
2) Osmotic agents (mannitol, urearetics)
3) Loop agents (eg, furosemide)
4)
Nephron Pathophysiology ... ) Loop agents (eg ... Adenosine #Nephron #Pathophysiology ... Sites #Action #nephrology ... #pharmacology
Serotonin-Norepinephrine Reuptake Inhibitors(SNRIs): Mechanisms and Side Effects

Withdrawal: Dizziness, Diarrhea, Insomnia, Nausea, Vomiting
Serotonin Syndrome - Potentially Life
- Cognitive Changes ... SerotoninNorepinephrine #Inhibitors #Pathophysiology ... #Pharmacology # ... Psychiatry #Diagnosis #Signs
Heparin, Fondaparinux, and Novel Oral Anticoagulants - Pathophysiology

Anticoagulation with parenteral (intravenous or subcutaneous) and oral anticoagulants
Anticoagulants - Pathophysiology ... anticoagulant (e.g ... conformational changes ... conformational change ... #Pharmacology #Pathophysiology
Pediatric SVT - Management Algorithm
Identify SVT:
 • HR not variable
 • Abrupt rate changes
 • Infants:
• Abrupt rate changes ... : HR > 180bpm ECG ... Monitors, Pads AP Stable ... Signs of shock or
Approach to Headaches - Differential Diagnosis Algorithm

Red flags (PHANTOMS):
 • Pattern change, progressively worse, papilledema
 •
): • Pattern change ... • Meningeal signs ... Systemic symptoms and signs ... CNS infection (e.g ... Diagnosis #Algorithm #neurology
Mechanisms of Drug-Induced Hyperkalemia 
 • Direct renin inhibitor (Aliskiren)
 • Renin release inhibition (NSAIDs, Beta-Blockers)
Heparin) • Sodium-channel ... • Increased EC ... differential #diagnosis #pathophysiology ... #pharmacology #
Leukostasis vs Tumor Lysis Syndrome
Leukostasis:
 • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
Leukostasis: • Pathophysiology ... tinnitus, visual changes ... WBC >100k, + lab signs ... Lysis Syndrome: • Pathophysiology ... unless worrisome EKG
Benign Prostatic Hyperplasia: Pathogenesis and Medications
Aging
 -> Increased Testosterone -> Testosterone metabolized into DHT by type
alpha-1 blockers (e.g ... -5 inhibitors (e.g ... Hyperplasia #Prostate #Pathophysiology ... #Medications #Pharmacology ... #Urology
Causes of Secondary Hypertension - Workup and Differential Diagnosis
Approach (when evaluation should be done):
1. Severe or
with previously stable ... hypertension and signs ... heart failure, neurologic ... renal bruit or signs ... Neurologic disorders