19 results
Immune-related adverse events (irAE) of  immune checkpoint inhibitors (ICI) 

- By Antoine Briantais 
Dr. Benjamin
irAE) of immune checkpoint ... #irAE #ICI #CheckpointInhibitors
Immune Checkpoint Inhibitor Toxicity

Main Toxicities: Colitis,  
Pneumonitis, Skin adverse events, Endocrine dysfunction, 
Hepatitis,  
Myocarditis,
Immune Checkpoint ... Treatment #Immune #CheckpointInhibitor
Check point inhibitors and Side Effects - Immune-related adverse events (IRAEs)

What are the side effects?
 -
by stopping the checkpoint ... immunosuppresion #CheckPointInhibitors
Pulmonary complications of targeted therapy
-Immune checkpoint inhibitors (e.g. pembrolizumab)
-Pneumonitis is uncommon (~5% of patients) but can
therapy -Immune checkpoint ... Radiology #Honc #CheckpointInhibitors
Immune Checkpoint Inhibitor-Mediated Colitis
Grade of Disease Severity:
 • G1: Increase < 4 BMs/day over baseline; mild
Immune Checkpoint ... Waseem_AhmedMD #Immune #CheckpointInhibitor
The Cell Cycle
The cell cycle is the series of tightly regulated steps that controls cell growth
through the G1/S checkpoint ... /S, S/G2, G2/M checkpoints ... the cell cycle checkpoints ... proliferation #TF #E2F #checkpoint
Undifferentiated shock - Algorithm for the Evaluation of Hypotension. This process for the evaluation of hypotension
halting at evaluable checkpoints
Myocarditis 

5 Principles of
Myocarditis:
1. Build clinical suspicion
2. Decide on EMBx
3. Manage acute cardiac injury
4. Manage chronic
anti-metabolite - Immune Checkpoint
Aortitis - Differential Diagnosis Framework
Non-Infectious Aortitis:
 • Vasculitides: Giant Cell Arteritis (GCA), Takayasu's arteritis, Cogan's Syndrome,
Erdheim-Chester), Immune Checkpoint
VITAMINS Mnemonic for Acute / Subacute Peripheral Polyneuropathy

Vascular
Inflammatory: Amyloidosis, vasculitis (often more subacute/chronic)
Toxins: Nitrous oxide, chemo,
oxide, chemo, checkpoint