Checkpoint immune causes pocus - GrepMed

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Immune-related adverse events (irAE) of immune checkpoint inhibitors (ICI)

- By Antoine Briantais
Dr. Benjamin

Immune-related adverse ... events (irAE) of immune ... checkpoint inhibitors

Aortitis - Differential Diagnosis Framework
Non-Infectious Aortitis:
• Vasculitides: Giant Cell Arteritis (GCA), Takayasu's arteritis, Cogan's Syndrome,

(SPA) • Other Causes ... Erdheim-Chester), Immune ... Checkpoint Inhibitors ... common bacterial causes ... Mycobacterial Causes

Check point inhibitors and Side Effects - Immune-related adverse events (IRAEs)

What are the side effects?
-

Side Effects - Immune-related ... - Immune-related ... - Most immune-related ... by stopping the checkpoint

Immune Checkpoint Inhibitors

PD-1 inhibitors
- Nivolumab
- Pembrolizumab
CTLA-4 inhibitors
- Ipilimumab
- Tremelimumab
PD-L1 inhibitors
- Atezolizumab

Immune Checkpoint ... Durvalumab #Immune ... #Checkpoint #Inhibitors

Undifferentiated shock - Algorithm for the Evaluation of Hypotension. This process for the evaluation of hypotension

In the case above ... halting at evaluable checkpoints ... Hypotension #Evaluation #POCUS

Checkpoint Inhibitors: Immune-Related Adverse Events (irAEs)

#Checkpoint #Inhibitors #SideEffects #AdverseEffects #irAEs #diagnosis #Incidence

Checkpoint Inhibitors ... : Immune-Related ... Events (irAEs) #Checkpoint

Myocarditis

5 Principles of
Myocarditis:
1. Build clinical suspicion
2. Decide on EMBx
3. Manage acute cardiac injury
4. Manage chronic

anti-metabolite - Immune ... Checkpoint Inhibitors

Immune Checkpoint–Blocking Antibodies Approved by the Food and Drug Administration #Pharm #Honc #Checkpoint #Blockade #FDA #Antibodies

Immune Checkpoint–Blocking ... #Pharm #Honc #Checkpoint

Eosinophils (Eos) and hypereosinophilia (HE)
Caused by eosinophilopoietic cytokines
Common causes:
- Drug reaction
- Helminth infection
-

hypereosinophilia (HE) Caused ... cytokines Common causes ... disease Rare causes ... malignancy - Immune ... Differential #Diagnosis #Causes

$Causes of Acute Kidney Injury (AKI) - Differential Diagnosis Algorithm Acute Kidney Injury (AKI) - Acute increase$

Causes of Acute ... antibodies • Immune-complex ... lupus) • Pauci-immune ... legionella) • Immune ... Diagnosis #Algorithm #Causes

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