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Classification of Jaundice Unconjugated hyperbilirubinemia (predominantly indirect bilirubin) • Increased bilirubin production (eg, hemolytic anemias, hemolytic reactions,
• Hereditary Cholestatic ... , and some cases ... ) Intrahepatic cholestasis ... miscellaneous causes ... #differential #causes
Liver Enzymes (LFTs) - Causes of Hepatocellular and Cholestatic Liver Injury Hepatocellular Liver Injury • AST/ALT elevation
Enzymes (LFTs) - Causes ... Hepatocellular and Cholestatic ... Hepatocellular or Cholestatic ... R ≤ 2 = Cholestatic ... Hepatocellular #Cholestatic
Causes of Acute Liver Injury - Differential Diagnosis Hepatocellular - Liver Parenchyma • Infectious: Hepatitis C, A,
Causes of Acute ... Thrombus, Vasospasm Cholestatic ... Hepatitis, TB Cholestatic ... Differential #Diagnosis #Causes
Drugs Causing Acute Pancreatitis Class Ia: The medications in which there was a rechallenge and other causes
rechallenge and other causes ... out other common causes ... Class II: Cases ... and atleast4 case ... #Pancreatitis #Causes
Cholestatic Liver Disease: Primary Biliary Cirrhosis vs Primary Sclerosing Cholangitis #pathophysiology #pbc #psc #hepatology #comparison
Cholestatic Liver
Evaluation abnormal liver tests in pregnancy - Cholestatic Pattern - Hepatocellular Pattern #LFTs #transaminits #pregnancy #obgyn #obstetrics #hepatology #diagnosis
in pregnancy - Cholestatic
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
Algorithm Vascular Causes ... poisoning, ETOH Cholestatic ... elevation Labs in Cholestatic ... epithelia: - Cholestasis ... ALT: typical of cholestatic
Jaundice - Differential Diagnosis Algorithm Pre-Hepatic - Unconjugated Hyperbilirubinemia Increased Production • Hemolysis • Ineffective Erythropoiesis • Hematoma Decreased
Hepatocellular • Cholestatic ... Diagnosis #Algorithm #Causes
Liver Function Test (LFTs) Elevation AST - Cardiac and skeletal muscle, kidney, brain ALT - More specific for
ALT ≥ 3x ULN Cholestatic ... pattern ≤2: Cholestatic
Pruritus - Generalized Differential Diagnosis Algorithm - Systemic and Primary Causes == Primary Skin Lesions == Macules /
Systemic and Primary Causes ... Tests/Enzymes: • Cholestatic ... Diagnosis #Algorithm #causes
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