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diagnosis differential rheumatology shock criticalcare hematology hemophagocytic hlh lymphohistiocytosis neurology overview treatment cell cellulitis cerebritis cns erythematosus hemeonc histiocytosis idsa
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
→Activation of CD8 ... accumulation of clinical ... Assessment • Clinical ... , Hb), Hepatic dysfunction ... Lymphohistiocytosis #diagnosis #management
SEPSIS AND SEPTIC SHOCK DEFINITION AND PATHOPHYSIOLOGY • Sepsis: Life-threatening organ dysfunction due to a dysregulated host
cytokines, complement activation ... COMMON CAUSES + ... CLINICAL RECOGNITION ... CLINICAL FEATURES ... INITIAL MANAGEMENT
Shock Overview A state of tissue hypoxia due to decreased or dysregulated oxygen delivery or extraction, resulting
death -> end-organ dysfunction ... death Common Clinical ... #diagnosis #management ... #differential #causes ... #classification
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
Macrophage Activation ... IL-1 and IL-6, leading ... Fever is the main clinical ... nervous system (CNS) dysfunction ... Syndrome #Diagnosis #Management
Transverse Myelitis Overview Focal inflammatory disorder of the spinal cord resulting in rapid onset of weakness, sensory
bowel or bladder dysfunction ... • Excessive activation ... Transverse Myelitis - Clinical ... • Infectious causes ... Myelitis #diagnosis #management
Shock Overview A state of tissue hypoxia due to decreased or dysregulated oxygen delivery or extraction, resulting
death -> end-organ dysfunction ... death Common Clinical ... #diagnosis #management ... #differential #causes ... #classification
CNS Manifestations of Systemic Lupus Erythematosus (SLE) Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
Erythematosus (SLE) Clinical ... Encephalopathy, Cognitive Dysfunction ... autoantibodies that will cause ... inflammation, leading ... cerebritis #diagnosis #management
IDSA Algorithm for the Management of Purulent skin and soft tissue infections (SSTIs). Mild infection: for
IDSA Algorithm for ... the Management ... or those with clinical ... evidence of organ dysfunction ... including those caused
Hemophagocytic Lymphohistiocytosis (HLH) High mortality without prompt recognition and management. HLH is a critical diagnostic consideration in
recognition and management ... cytopenias and organ dysfunction ... hyperinflammatory syndrome caused ... Persistent fever, organ dysfunction ... Clinical Presentation
Langerhans Cell Histiocytosis (LCH) Granulomatous Lesions comprising langerin-positive histiocytes and an inflammatory infiltrate can arise in virtually
various tissues, leading ... populations) CLINICAL ... • Endocrine Dysfunction ... Birbeck granules (EM ... Histiocytosis #Diagnosis #Management
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