8 results
Lymphomas and Lymphoproliferative Disorders - Differential Diagnosis Algorithm
Hodgkin Lymphoma ~40% - Characteristic For Reed-Sternberg (RS) Cells
Differential Diagnosis Algorithm ... Lymphoproliferative #Disorders #Classification ... #pathophysiology ... #Hematology #Diagnosis ... #differential #algorithm
Hypersensitivity Types and Their Mechanisms
Type I - lgE - Soluble antigen
 - Allergen-specific lgE antibodies bind
cellular antigen, leading ... Complement activation ... Hypersensitivity #Types #Classification ... #Pathophysiology ... Diagnosis #Reactions #Table
Hemophagocytic Lymphohistiocytosis (HLH)
Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
Lymphohistiocytosis (HLH) Pathophysiology ... →Activation of CD8 ... IFN-y) → Excessive activation ... , Hb), Hepatic dysfunction ... Lymphohistiocytosis #diagnosis #management
Macrophage Activation Syndrome (MAS)
Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH)

What?
A subset of
Macrophage Activation ... IL-1 and IL-6, leading ... nervous system (CNS) dysfunction ... Syndrome #Diagnosis #Management ... #Hematology #Rheumatology
CNS Manifestations of Systemic Lupus Erythematosus (SLE)

Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
Encephalopathy, Cognitive Dysfunction ... Disease, PRES Pathophysiology ... inflammation, leading ... CNS #neurology #rheumatology ... cerebritis #diagnosis #management
Shock Classification
Shock Definition: State of cellular and tissue hypoxia due to: reduced oxygen delivery, increased oxygen
Shock Classification ... END-ORGAN DYSFUNCTION ... Hemorrhagic → leading ... Types #diagnosis #management ... warm #wet #dry #table
IGG-4 RELATED DISEASE

WHAT?
 • A chronic, immune-mediated fibroinflammatory disease with tumefactive infiltration of IgG4+ plasma cells
- Organ dysfunction ... PATHOPHYSIOLOGY ... progressive organ dysfunction ... complement • Classification ... #Rheumatology
Hemophagocytic Lymphohistiocytosis (HLH)

High mortality without prompt recognition and management. HLH is a critical diagnostic consideration in
recognition and management ... cytopenias and organ dysfunction ... Persistent fever, organ dysfunction ... Pathophysiology ... #Hematology #HemeOnc