15 results
Pharmacokinetic Characteristics and Primary Routes of Clearance of Oral Anticoagulant Agents

Warfarin - 100% Hepatic, 0% Renal
Apixaban
Primary Routes of Clearance ... of Oral Anticoagulant ... Hepatic, 0% Renal Apixaban ... Hepatic, 80% Renal Edoxaban ... Hepatic, 35% Renal #DOAC
Oral anticoagulant dosing and bridging for VTE

- Dr. Joseph Shatzel @Clotmaster 

#VTE #DOAC #Bridging #Dosing #Oral
Oral anticoagulant ... dosing and bridging ... Clotmaster #VTE #DOAC ... Anticoagulation #Dabigatran #Apixaban ... #Rivaroxaban #Edoxaban
DOAC: Cheat Sheet - Atrial Fibrillation, VTE Prophylaxis, VTE and Renal Dosing

Renal Dosing:
Apixaban (25% renal clearance):
: Apixaban (25% ... renal clearance ... if CrCl < 50) Edoxaban ... #Pharmacology #Apixaban ... Rivaroxaban #Dabigatran #Edoxaban
DOAC Cheat Sheet
 • Apixaban, Dabigatran, Edoxaban, Rivaroxaban
 • Renal Dosing
 • Common Drug interactions
 •
DOAC Cheat Sheet ... • Apixaban, Dabigatran ... , Edoxaban, Rivaroxaban ... • Renal Dosing ... DeLoughery @Bloodman #DOAC
Warfarin to DOAC and DOAC to Warfarin Transitions 

Here are a couple of charts to help
Warfarin to DOAC ... and DOAC to Warfarin ... for easier dosing ... Quick tip: apixaban ... Edoxaban is <2.5
Patient risk stratification algorithm for the treatment of cancer-associated thrombosis.

Currently, edoxaban and rivaroxaban are the only
Currently, edoxaban ... direct-acting oral ... being stronger for edoxaban ... for appropriate dosing ... direct-acting oral
Perioperative Management of DOACs
Problem:
 ✖ Each year approximately 250,000 patients on chronic anticoagulation in North America
direct acting oral ... recent creatinine clearance ... (calculated using ... inhibitor) • Apixaban ... , Edoxaban, Rivaroxaban
Choice of anticoagulant for treatment of pulmonary embolism
 • Malignancy - LMWH
 • To avoid parenteral
- Rivaroxaban; apixaban ... • Once a day oral ... - Rivaroxaban; edoxaban ... with creatinine clearance ... Gl bleed - VKA, apixaban
DOAC Reversal
Emergency surgery or urgent procedure
Stop anticoagulant treatment; volume resuscitation and transfusion as needed
Antidotes:
 • Apixaban,
DOAC Reversal Emergency ... Antidotes: • Apixaban ... , Edoxaban or Rivaroxaban ... not available #DOAC ... #Oral #anticoagulant
Xa Inhibitors - Apixaban and Rivaroxaban 
Oral Xa inhibitors are recommended by CHEST as first-line for
Xa Inhibitors - Apixaban ... Rivaroxaban Oral ... indications and edoxaban ... overview of the dosing ... #Rivaroxaban #Dosing