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Drug Clearance and Pharmacokinetics Considerations in ECMO

- Infographic by Dr. Catherine Beni @totalbodydolor 

#ECMO #Pharmacology #Drug
Drug Clearance and ... totalbodydolor #ECMO #Pharmacology ... #Drug #Clearance
Pharmacokinetic Characteristics and Primary Routes of Clearance of Oral Anticoagulant Agents

Warfarin - 100% Hepatic, 0% Renal
Apixaban
Primary Routes of Clearance ... NOAC #Metabolism #Pharmacology ... #Clearance #oral
Mechanism of Action of Bile Acid Sequestrants
Bile Acid Sequestrants → ↓ Hepatic Bile Acid Pool →
Receptors → ↑ LDL Clearance ... pathophysiology #pharmacology
Choice of anticoagulant for treatment of pulmonary embolism
 • Malignancy - LMWH
 • To avoid parenteral
with creatinine clearance ... anticoagulation #pharmacology
DOAC: Cheat Sheet - Atrial Fibrillation, VTE Prophylaxis, VTE and Renal Dosing

Renal Dosing:
Apixaban (25% renal clearance):
Apixaban (25% renal clearance ... Anticoagulation #Hematology #Pharmacology
Adult Vancomycin Guidelines
The information below provides general dosing guidelines for vancomycin. A maintenance regimen of 15-20
current creatinine clearance ... #Management #Pharmacology
Heparin - Unfractionated Heparin (UFH) vs Low-Molecular-Weight Heparin (LMWH)
UFH:
 • Advantages: 
    -
Rapid onset and clearance ... Unfractionated #pharmacology
Perioperative Management of DOACs
Problem:
 ✖ Each year approximately 250,000 patients on chronic anticoagulation in North America
recent creatinine clearance ... Management #Treatment #pharmacology
Management of Diabetes Mellitus in Patients With CKD

1. Monitor for changes in BP, serum creatinine, &
decreased creatinine clearance ... evidence-based pharmacologic
Algorithm for the evaluation of pediatric cervical spine injuries #Diagnosis #EM #Peds #Trauma #CSpine #Clear #Clearance
CSpine #Clear #Clearance