14 results
Rapidly Progressive Glomerulonephritis (RPGN)
RPGN has three primary pathophysiologic causes differentiated by immunofluorescence

Immune Complex Mediated (granular staining):
pathophysiologic causes ... ANCA (C-ANCA): GPA ... Glomerulonephritis #Vasculitis ... #differential #diagnosis ... #algorithm #rheumatology
Purpura - Differential Diagnosis Framework

Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
- Differential Diagnosis ... - GPA - EGPA ... reactions • Erythema gangrenosum ... #Differential #Diagnosis ... #hematology #rheumatology
Dermatologic Manifestations of Granulomatosis with Polyangiitis (GPA)

Skin involvement in granulomatosis with polyangiitis (GPA) is common and
GPA causes disease ... Rarely dominate the clinical ... resemble pyoderma gangrenosum ... Differential Diagnosis ... #diagnosis #rheumatology
Dermatological semiology of Cutaneous Vasculitis 

Clinicopathologic correlations
 • Purpura, papules, pustules, necrosis: involvement of small vessels
Identification of causes ... (5%): PAN > GPA ... #dermpath #dermatology ... signs #lesions #diagnosis ... #clinical #manifestations
Pyoderma Gangrenosum: Autoimmune disorder resulting in a vasculitis which causes slowly progressive 
ulceration of the skin.
Pyoderma Gangrenosum ... resulting in a vasculitis ... which causes slowly ... Images #Clinical ... #Photo #Dermatology
Skin Ulcers of the Lower Legs / Feet - Differential Diagnosis Algorithm
Physical:
• Pressure
• Trauma
• Radiation
Vascular:
• Arterial
- Differential Diagnosis ... Algorithm Physical ... insufficiency • Vasculitis ... Metabolic: • Pyoderma gangrenosum ... #Algorithm #causes
ANCA-Associated Vasculitis
There are many definitions, but most come down to the presence of granulomas (pathologically or
ANCA-Associated Vasculitis ... pathologically or clinically ... polyangiitis (GPA ... #differential #diagnosis ... #algorithm #rheumatology
Skin Ulcers by Etiology - Differential Diagnosis Algorithm
Physical:
 • Trauma
 • Pressure
 • Radiation
Vascular:
 • Arterial
Algorithm Physical ... insufficiency • Vasculitis ... : • Pyoderma gangrenosum ... • Bleomycin Hematologic ... #Algorithm #causes
Causes of Petechial Rash - Differential Diagnosis Algorithm

Pinpoint areas (less than 2 mm) of hemorrhage, which
Causes of Petechial ... - Differential Diagnosis ... Algorithm Pinpoint ... RA, Sjogren's, GPA ... #Algorithm #Causes
Cryoglobulinemia Summary

Cryoglobulins:
 • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
• They can cause ... Cryoglobulins Cause ... Syndrome: • Clinical ... Labs/Diagnosis: ... - GPA, EGPA, microscopic