851 results
COVID-19 Life Cycle

#COVID19 #LifeCycle #Timeline #Pathophysiology #Diagnosis
Cycle #COVID19 #LifeCycle ... #Timeline #Pathophysiology
Shock Classification and Differential Diagnosis
SHOCK
 • MAP <65, SBP <90, drop in SBP > 40
 •
Distributive: • High CO ... Cardiogenic: • Low CO ... Obstructive: • Low CO ... Hypovolemic: • Low CO
Shock - Differential Diagnosis Framework
MAP = CO x SVR
Hypovolemic (↓ Intravascular volume):
 • Hemorrhage, dehydration due
Framework MAP = CO ... third-spacing • ↓ CO ... arrhythmia • ↓ CO ... PE, PAH • ↓ CO ... drugs/toxins • ↑ CO
High Output Heart Failure - Pathophysiology and Differential Diagnosis
Obesity - Systemic Vasodilation, Vasoactive Adipokines
Arteriovenous Fistula -
Heart Failure - Pathophysiology ... Anemia - Increased CO ... HeartFailure #CHF #Pathophysiology
POCUS - Measuring Cardiac Output
1) Calculate LVOT Area
2) Calculate LVOT VTI
3) Calculate Cardiac Output

SV = (LVOT
) x (LVOT VTI) CO ... LVOT VTI) X HR CO ... Cardiac #Output #CO
Oxygen Delivery Equation
DO2 = CO x {(1.39 x Hb x sO2) + (PaO2 x 0.03)}
DO2 =
Equation DO2 = CO ... delivery in mL/min CO ... Cardiac output (CO ... Delivery #Equation #pathophysiology
Benzodiazepines: Mechanism of Action and Side Effects
 • Decr spinal cord activity -> Muscle relaxant
- Rare unless co-ingestion ... #Pharmacology #pathophysiology
Vasopressors and Inotropes - Pharmacology Summary
Vasopressors
Phenylephrine (alpha-1)
 • Increases BP, SVR
 • Risk of reflex bradycardia
Increases BP, SVR, CO ... Increases HR, SVR, CO ... contractility, CO ... • Increases CO
Leishmaniasis Life Cycle
1) Sandfly takes a blood meal (injects promastigote stage into the skin)
Human Stages:
2) Promastigotes
Leishmaniasis #LifeCycle ... #diagnosis #pathophysiology
Diabetes Pathophysiology and Medication Targets

The ominous octet is one concept that summarizes the different pathophysiologic pathways
Diabetes Pathophysiology ... the different pathophysiologic ... #Diabetes #Pathophysiology