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Non-HCV infectious mixed cryoglobulinemia vasculitis - Diagnosis, causes and management - French Vasculitis Study Group

< 5%
Non-HCV infectious ... vasculitis - Diagnosis ... , causes and management ... vasculitis Clinical ... #Diagnosis #Management
Diagnosis of Cryoglobulinemia Vasculitis

1) Presence of cryoglobulin 
Circulating immunoglobulins that precipitate with cold temperature and dissolve
Diagnosis of Cryoglobulinemia ... Vasculitis 1 ... not related to clinical ... Hyperviscosity syndrome ... #Vasculitis #Diagnosis
Cryoglobulinemia Summary

Cryoglobulins:
 • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
Syndrome: • Clinical ... • Infections: HCV ... infection, HBV ... Labs/Diagnosis: ... Cryoglobulins #diagnosis
Vasculitis and Vasculitides - Differential Diagnosis Framework

When to Consider Vasculitis:
 • Purpura, ischemic skin lesions
 •
- Differential Diagnosis ... ANCA +MPO) • Cryoglobulinemic ... • Cogan Syndrome ... Low levels mixed cryoglobulinemia ... • HBV HCV
Dermatologic Manifestations of Granulomatosis with Polyangiitis (GPA)

Skin involvement in granulomatosis with polyangiitis (GPA) is common and
Rarely dominate the clinical ... Palpable purpura • Vesicles ... Differential Diagnosis ... purpura • Mixed cryoglobulinemia ... • Goodpasture syndrome
Vasculitis - Differential Diagnosis Framework

When to Consider Vasculitis:
• Purpura, ischemic skin lesions
• Mononeuritis multiplex
• Hematuria, proteinuria,
Diagnosis Framework ... Differential Diagnosis ... HTN • Check: HBV ... / ANCA + MPO) Cryoglobulinemic ... legs), cutaneous vesicles
Paraproteinemias

Entities That Can Feature A Monoclonal Protein/M Component:
• MM
• WM
• MGUS
• MGCS
• MGRS
• Splenic Marginal Zone
Zone Lymphoma (HCV ... Immunotactoid GN & Cryoglobulinemic ... Autoimmunity: • -MM/WM: Vasculitis ... (Cryoglobulinemic ... #Differential #Diagnosis
Vancomycin induced Leukocytoclastic Vasculitis (LCV) of the Hand
70 M vertebral osteomyelitis on vancomycin and cefepime for
Diagnosis? ... Churg-Strauss syndrome ... #LCV #Hand #skinrash ... #dermatology #clinical ... #photo
Acute Kidney Injury - AKI Workup Algorithm and Differential Diagnosis
Baseline Investigations: full blood count with differential,
Differential Diagnosis ... investigations depending on clinical ... Glomerulonephritis / Vasculits ... hepatitis serology, HIV ... • Cardio-renal syndrome
Cryofibrinogenemia Summary

Cryofibrinogenemia Epidemiology:
 • 40-70 years with a modest female predominance

Cryofibrinogenemia:
 • The precipitation of a
malignancies, vasculitis ... , sepsis or cryoglobulinemia ... Cryofibrinogenemia Clinical ... : • + Clinical ... Antiphospholipid syndrome