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Anemias - Differential and Diagnostic Clues

Ariella Coler-Reilly @AriellaStudies

#Anemias #Differential #Diagnosis #Clues #Hematology
Anemias - Differential ... Ariella Coler-Reilly ... AriellaStudies #Anemias ... #Differential # ... #Hematology
Aplastic Anemia - Overview

Who?
• M = F
• 3 peaks:	1) Childhood	2) 15-25 years	3) >60 years

What?
• Aplastic anemia
Aplastic Anemia ... • Aplastic anemia ... Immune Aplastic Anemia ... and petechiae Causes ... #oncology #hematology
Gastrointestinal Causes of Iron Deficiency Anemia
 • Mass lesions: Carcinoma, Large polyps
 • Inflammatory: Reflux esophagitis,
Iron Deficiency Anemia ... Duodenal ulcer, SB or colon ... rubber bleb nevus syndrome ... Iron #Deficiency #Anemia ... #Causes #differential
Diagnostic Framework for Anemia (Morphological Approach - MCV)
Low MCV - <80fL - "Microcytic"
 • Iron deficiency
Framework for Anemia ... thalassemia • Anemia ... Myelodysplastic syndrome ... morphologic #mcv #differential ... #diagnosis #causes
Causes of Anemia with elevated Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm
Normal Blood Smear
 •
Causes of Anemia ... • Pernicious Anemia ... • Pernicious Anemia ... Myelodysplastic Syndromes ... #Macrocytic #Anemia
Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary
myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
Myelodysplastic Syndrome ... old, ~10,000 new cases ... cytopenias (usually anemia ... Myelodysplastic #Syndrome ... #oncology
Causes of Thrombocytopenia - Differential Diagnosis Algorithm
 
Decreased Megakaryopoiesis
 • Aplastic Anemia
 • Toxic Damage (e.g.
Causes of Thrombocytopenia ... - Differential ... Megakaryopoiesis • Aplastic Anemia ... Non-lmmune: • HELLP Syndrome ... #Hematology
Dyspnea - Differential Diagnosis Framework

Cardiovascular Causes of Dyspnea:
 • Myocardium:
	- Heart failure
	- CAD/ACS
	- Valvulopathy
 • Electrical:
	-
Dyspnea - Differential ... Hepatopulmonary syndrome ... Transverse myelitis • Hematology ... : - Anemia • ... #dyspnea #sob #differential
Micronutrient Deficiencies After Gastric Bypass
Fat-Soluble Vitamins:
 • Vitamin A - Night/complete blindness, xeropthalmia (pathologic dryness of
non-specific skin rash ... Folate - Macrocytic anemia ... B12 - Macrocytic anemia ... Minerals: • Iron - Anemia ... cognitive dysfunction, anemia
Causes of Thrombocytosis - Differential Diagnosis
Secondary Thrombocytosis (a.k.a Reactive Thrombocytosis):
 • Acute infection
 • Solid organ
Causes of Thrombocytosis ... - Differential ... malignancies • Anemia ... Myelodysplastic syndrome ... #hematology #secondary