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diagnosis rheumatology differential lupus management algorithm nephrology types vasculitis hepatology causes dermatology erythematosus sle anemia comparison systemic table clinical oncology
Rapidly Progressive Glomerulonephritis (RPGN) RPGN has three primary pathophysiologic causes differentiated by immunofluorescence Immune Complex Mediated (granular staining):
Rapidly Progressive Glomerulonephritis ... staining): • Low Complement ... Idiopathic • Normal Complement ... Kidney: Anti-GBM Glomerulonephritis ... diagnosis #algorithm #rheumatology
Causes of Hypocomplementemia - CHAMPS Mnemonic C - Cryoglobulinemia (85%), C3 glomerulopathy, cirrhosis H - Heavy Chain deposition
Membranoproliferative glomerulonephritis ... Post/pauci immune glomerulonephritis ... Hypocomplementemia #Low #Complement ... #differential #hematology
Membranoproliferative Glomerulonephritis (MPGN) AKA: Mesangiocapillary GN • Active Urine Sediment (dysmorphic RBC, RBC casts, +/- proteinuria)
Membranoproliferative Glomerulonephritis ... staining (lg + complement ... MGPN • Complement ... of alternative complement ... Membranoproliferative #Glomerulonephritis
Complement Pathways - Classical Pathway - Lectin Pathway - Alternative Pathway #Complement #Pathway #hematology #pathophysiology
Complement Pathways ... Alternative Pathway #Complement ... #Pathway #hematology
Glomerular Diseases - Nephritic and Nephrotic Syndromes Nephritic syndrome: - Acute poststreptococcal glomerulonephritis - Rapidly progressive
poststreptococcal glomerulonephritis ... Rapidly progressive glomerulonephritis ... proliferative glomerulonephritis ... Membranoproliferative glomerulonephritis ... Nephrotic #Syndromes #Classification
Causes of Hemolytic Anemia - Differential Diagnosis Inherited • Membrane • Internal - Hemoglobin
Antibody/DAT+ - Complement ... Diagnosis #Causes #hematology
EULAR/ACR Classification Criteria for Systemic Lupus Erythematosus Clinical Domains: • Constitutional domain: Fever • Cutaneous domain: Non-scarring
EULAR/ACR Classification ... pericarditis • Hematologic ... anticoagulant • Complement ... #EULARACR #Classification ... Erythematosus #diagnosis #rheumatology
Hypersensitivity Types and Their Mechanisms Type I - lgE - Soluble antigen - Allergen-specific lgE antibodies bind
antigen, leading to complement ... Complement activation ... Post-streptococcal glomerulonephritis ... Hypersensitivity #Types #Classification
Pulmonary Renal Syndromes and Mimics - Differential Diagnosis Framework Diffuse alveolar hemorrhage + rapidly progressive glomerulonephritis 90%: -
rapidly progressive glomerulonephritis ... anti-GBM) 10%: - Low Complement ... Vasculitis - Normal Complement
Summary table of types of hypersensitivity reactions. Type 1 - Mediators: lgE - Antigen Form: Soluble
antigens, leading to complement ... they activate complement ... Post-streptococcal glomerulonephritis ... allergy #table #classification
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