94 results
Rapidly Progressive Glomerulonephritis (RPGN)
RPGN has three primary pathophysiologic causes differentiated by immunofluorescence

Immune Complex Mediated (granular staining):
Rapidly Progressive Glomerulonephritis ... staining): • Low Complement ... Idiopathic • Normal Complement ... #Vasculitis #differential ... #diagnosis #algorithm
Pulmonary Renal Syndromes and Mimics - Differential Diagnosis Framework
Diffuse alveolar hemorrhage + rapidly progressive glomerulonephritis
90%:
 -
rapidly progressive glomerulonephritis ... ANCA Associated Vasculitis ... anti-GBM) 10%: - Low Complement ... - Normal Complement ... Renal Crisis, IgA Vasculitis
Vasculitis and Vasculitides - Differential Diagnosis Framework

When to Consider Vasculitis:
 • Purpura, ischemic skin lesions
 •
- Necrotizing glomerulonephritis ... , pauci-immune glomerulonephritis ... • Glomerulonephritis ... arthritis. (± glomerulonephritis ... against MPO • Complement
Membranoproliferative Glomerulonephritis (MPGN) AKA: Mesangiocapillary GN
 • Active Urine Sediment (dysmorphic RBC, RBC casts, +/- proteinuria)
Membranoproliferative Glomerulonephritis ... staining (lg + complement ... MGPN • Complement ... of alternative complement ... Membranoproliferative #Glomerulonephritis
A System for Vasculitides 

#Diagnosis #IM #Rheum #Vasculitis #Small #Medium #Large #Vessel #Size #Classification #ANCA #Differential
A System for Vasculitides ... Diagnosis #IM #Rheum #Vasculitis ... #Differential #Algorithm
Pathophysiology of Hypocomplementemic Urticarial Vasculitis

C1q/anti-C1q antibiody ->
Immune Complex Formation - Complement Pathway Activation (C3a and C5a)
Hypocomplementemic Urticarial Vasculitis ... Complex Formation - Complement ... Formation -> Vasculitis ... Hypocomplementemic #Urticarial #Vasculitis
Causes of Hypocomplementemia - CHAMPS Mnemonic
C - Cryoglobulinemia (85%), C3 glomerulopathy, cirrhosis
H - Heavy Chain deposition
Membranoproliferative glomerulonephritis ... Post/pauci immune glomerulonephritis ... Hypocomplementemia #Low #Complement
Diagnosis and management of Polyarteritis Nodosa (PAN)

Chapel Hill 2012 definition: 
Necrotizing vasculitis ofmedium or small arteries
Necrotizing vasculitis ... arteries without glomerulonephritis ... or vasculitis in ... involvement French Vasculitis ... Diagnosis #Management #Vasculitis
Cryoglobulinemia Summary

Cryoglobulins:
 • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
Skin ulcers - Glomerulonephritis ... • Low serum C4 complement ... • IgA vasculitis ... • Vasculitis ... #rheumatology #vasculitis
Approach to managing Glomerulonephritis (GN) in children. 

ANCA, antineutrophil cytoplasmic antibodies; c-ANCA, cytoplasmic antineutrophil cytoplasmic antibodies;
Approach to managing Glomerulonephritis ... #Glomerulonephritis ... #Algorithm #Nephrology