203 results
Complement Pathways
- Classical Pathway
- Lectin Pathway
- Alternative Pathway

#Complement #Pathway #hematology #pathophysiology
Complement Pathways ... Alternative Pathway #Complement ... Pathway #hematology #pathophysiology
Overview of the Complement System - Classical and Alternative Pathways

by Dr.Grace Leo @gracie_leo

#Complement #System #Classical #Alternative
Overview of the Complement ... gracie_leo #Complement ... Alternative #Pathways #Pathophysiology
Blood Disorders - Markers and Differential Diagnosis Algorithm 
Acute
 • Myloid (AML) - CD13, CD33, CD34,
- Markers and Differential ... - T-cell - CD7 ... , CD3 Chronic ... - B-cell CD5 ... hematology #Markers #Differential
Rapidly Progressive Glomerulonephritis (RPGN)
RPGN has three primary pathophysiologic causes differentiated by immunofluorescence

Immune Complex Mediated (granular staining):
three primary pathophysiologic ... staining): • Low Complement ... Idiopathic • Normal Complement ... Glomerulonephritis #Vasculitis #differential
Humoral Immunity - Pathogenesis and Clinical Findings
Antigens (Ag) are produced from pathogens (bacteria, viruses, fungi, parasites)
present Ag to CD4 ... activation • Complement ... tagged with C3 complement ... proliferate and differentiate ... Humoral #Immunity #pathophysiology
Pathophysiology of Hypocomplementemic Urticarial Vasculitis

C1q/anti-C1q antibiody ->
Immune Complex Formation - Complement Pathway Activation (C3a and C5a)
Pathophysiology ... Complex Formation - Complement ... Vasculitis #HUV #Pathophysiology
Inflammatory Cascade: Pathogenesis and Clinical Findings
Continued Innate Immunity
 • Phagocytosis: (main mechanism) neutrophils and macrophages engulf
dead tissue • Complement ... activation of complement ... #Inflammation #pathophysiology
Causes of Hemolytic Anemia - Differential Diagnosis
Inherited
 • Membrane
 • Internal
    - Hemoglobin
Hemolytic Anemia - Differential ... Antibody/DAT+ - Complement ... Hemolytic #Anemia #Differential
Effect of Selected Diseases on Complement Levels - C3, C4
 • SLE C3 ↓ C4 ↓↓
Selected Diseases on Complement ... ThePeanutKidney #Complement ... Levels #C3 #C4 #differential
C5-C9 Deficiency - Pathogenesis and Clinical Findings
Note:
 • Risk of invasive meningococcal disease is 1000-10000x higher
is rare Normal complement ... response: The complement ... activation -> Complement ... C7, C8, C9 -> Complement ... #pathophysiology