12 results
Rapidly Progressive Glomerulonephritis (RPGN)
RPGN has three primary pathophysiologic causes differentiated by immunofluorescence

Immune Complex Mediated (granular staining):
Rapidly Progressive ... three primary pathophysiologic ... staining): • Low Complement ... RPGN #Rapidly #Progressive ... differential #diagnosis #algorithm
Algorithmic Approach to Acute Interstitial Nephritis
When to suspect AIN? (not sensitive)
 • AKI, AKD, rapidly progressive
Algorithmic Approach ... , AKD, rapidly progressive ... (<10%): fever, rash ... Nephritis #AIN #Algorithm
Maculopapular - Diagnostic Algorithm
Pathophysiology:
- Catch-all term with a wide range of potential pathophysiologic mechanisms and causative
Maculopapular - Diagnostic Algorithm ... Pathophysiology ... New-onset fever with rash ... #Dermatology #Rash ... Color #Targetoid #Algorithm
C5-C9 Deficiency - Pathogenesis and Clinical Findings
Note:
 • Risk of invasive meningococcal disease is 1000-10000x higher
is rare Normal complement ... response: The complement ... activation -> Complement ... Maculopapular rash ... #pathophysiology
Erythroderma - Diagnostic Algorithm. Pathophysiology: 1) Extensive cutaneous capillary dilation, results in widespread exfoliation of the
Erythroderma - Diagnostic Algorithm ... Pathophysiology: ... #Dermatology #Rash ... Erythroderma #Nikolsky #Algorithm
Petechiae/Purpura - Diagnostic Algorithm. Pathophysiology: 1) Represent the passage of erythrocytes from the intravascular to extravascular
Purpura - Diagnostic Algorithm ... Pathophysiology: ... #Dermatology #Rash ... Purpura #Palpable #Algorithm
Lymphomas and Lymphoproliferative Disorders - Differential Diagnosis Algorithm
Hodgkin Lymphoma ~40% - Characteristic For Reed-Sternberg (RS) Cells
Differential Diagnosis Algorithm ... system (node) with progression ... Classification #pathophysiology ... #differential #algorithm
Cutaneous larva migrans skin Rash
25 F recent Caribbean vacation, walked barefoot on sand and now with
larva migrans skin Rash ... now with creepy rash ... progressive migrating ... serpiginous rash ... unable to complete lifecycle
Amebiasis - Balamuthia mandrillaris Life Cycle
1) Cysts
2) Trophozoite
3) Mitosis
4) Amebae (cysts and trophozoites) can enter humans
who are immune competent ... #mandrillaris #LifeCycle ... #diagnosis #pathophysiology
Vasculitis and Vasculitides - Differential Diagnosis Framework

When to Consider Vasculitis:
 • Purpura, ischemic skin lesions
 •
proteinuria, rapidly progressing ... mucositis - Rash ... against MPO • Complement