17 results
diagnosis lupus rheumatology differential classification management systemic allergy types vasculitis comparison genetics hypersensitivity iem inbornerrors laboratory metabolism neonatology nicu pediatrics
Systemic Lupus Erythematosus (SLE): Pathogenesis • Genetic factors (Mutations in HLA- DR2/HLA-DR3 genes, complement genes, cytokine
Systemic Lupus Erythematosus ... (SLE): Pathogenesis ... HLA-DR3 genes, complement ... Systemic #Lupus #Erythematosus ... #SLE #Pathophysiology
Systemic Lupus Erythematosus (SLE) - Diagnosis and Management Summary • Epidemiology: 10-180/100,000, Typically Age 20-40, F:M
Systemic Lupus Erythematosus ... (SLE) - Diagnosis ... Positive in 60-80% of cases ... 80% - Low complement ... lupus #Systemic #Erythematosus
Systemic Lupus Erythematosus (SLE): Musculoskeletal Manifestations • Immune Complex Deposition - Arthralgia, Arthritis
Systemic Lupus Erythematosus ... (SLE): Musculoskeletal ... Myopathy (Also caused ... #SLE #MSK #Musculoskeletal ... Complications #pathophysiology
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
90% - Low complement ... Discontinuation of causal ... Systemic Lupus Erythematosus ... 80% - Low complement ... #comparison #table
Type III Hypersensitivity: Pathogenesis and clinical findings Definition: Small antigen-antibody complexes (produced from normal immune response to
self-antigens are the cause ... Systemic Lupus • Erythematosus ... (SLE) If bacterial ... antigens are the cause ... Allergy #Immunology #pathophysiology
A schema of the pathophysiology of the inborn errors of metabolism, excluding complex storage diseases. Helps
schema of the pathophysiology ... See the lab values ... table for supplemental ... #Diagnosis #Algorithm ... Peds #Pediatrics #Table
Rapidly Progressive Glomerulonephritis (RPGN) RPGN has three primary pathophysiologic causes differentiated by immunofluorescence Immune Complex Mediated (granular staining):
three primary pathophysiologic ... causes differentiated ... staining): • Low Complement ... Idiopathic • Normal Complement ... differential #diagnosis #algorithm
Lab patterns seen in Inborn Errors of Metabolism A table of lab values compiled from UpToDate and
Metabolism A table ... See IEM schema for ... metabolicemergency-pathophysiology-differential-pediatrics-metabolism-algorithm-diagnosis ... Peds #Pediatrics #Table
CNS Manifestations of Systemic Lupus Erythematosus (SLE) Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
Systemic Lupus Erythematosus ... (SLE) Clinical ... Disease, PRES Pathophysiology ... autoantibodies that will cause ... #SLE #CNS #neurology
Hypersensitivity Types and Their Mechanisms Type I - lgE - Soluble antigen - Allergen-specific lgE antibodies bind
antigen, leading to complement ... Complement activation ... systemic lupus erythematosus ... Classification #Pathophysiology ... Diagnosis #Reactions #Table
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