7 results
Candidemia Workup and Management - IDSA Guidelines
1) Antibiotics
 • Empiric: Echinocandins (e.g. micafungin) for most patients
Candidemia Workup ... Susceptibilities, Negative ... or TEE unless clinical ... #candida #candidiasis ... #treatment #fungal
My Patient with Infective Endocarditis (IE) Has Negative Blood Cultures
 - Did they receive antibiotics prior
therapy - Number one cause ... Fungal (Histoplasma ... patient a surgical candidate ... BloodCultures #Diagnosis #Management ... #Algorithm
Fungal Biomarkers: Beta-D-Glucan and Aspergillus Galactomannan
Beta-D-Glucan:
 • Polysaccharide cell wall component of many fungi
 • Pathogens:
Polysaccharide cell wall component ... • Pathogens: Candida ... Coccidioides - Negative ... cut-offs defined in clinical ... BAL GM does not differentiate
Blood Culture-Negative Infective Endocarditis (BCNIE)
Definition: No etiology found after 3 separate blood cultures remain negative for
microbiological techniques Work-up ... antimicrobials, clinical ... but important causes ... (Aspergillus, Candida ... Endocarditis #diagnosis #differential
1,3-Beta-D-Glucan and Galactomannan Testing Sensitivity Specificity and False Positives
1,3-Beta-D-Glucan
 • Cell wall component of many fungi
• Cell wall component ... • Routine use: Candida ... Almost always negative ... >90% (In most clinical ... in BAL does not differentiate
SEPSIS AND SEPTIC SHOCK

DEFINITION AND PATHOPHYSIOLOGY
 • Sepsis: Life-threatening organ dysfunction due to a dysregulated host
Gram-positive/-negative ... bacteria, fungi ... (e.g., Candida) ... CLINICAL RECOGNITION ... CLINICAL FEATURES
It is important to recognize Acute Decompensated Heart Failure (ADHF) as more than just simply a
just simply a clinical ... have achieved negative ... the determined cause ... #diagnosis #differential ... #algorithm #management