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differential causes infectiousdiseases lung management pulmonary abscess acute aspergillus bacteremia betadglucan biomarkers chronic diseases encephalopathy eosinophilia eosinophilic fuo galactomannan infections
Fever - Pyrogen Pathophysiology EXOGENOUS PYROGEN • Bacteria: Lipopolysaccharide components, peptidoglycans and muramyl peptide derivatives, Toxins •
Pathophysiology ... Lipopolysaccharide components ... stranded RNA • Fungi ... - Transport to brain ... #Fever #Pathophysiology
Causes of Fever of Unknown Origin (FUO) - Differential Diagnosis Algorithm Neoplasm: • NHL • Hodgkin's lymphoma • Leukemia • Solid
- Differential Diagnosis ... Algorithm Neoplasm ... Infection: • Fungal ... malaria) • other parasites ... #Algorithm #causes
Rigors And Bacteremia - Overview • Rigors are a response to the release of cytokines and prostaglandins
hypothalamus → fever ... PATHOPHYSIOLOGY: ... Double-stranded RNA • Fungi ... Transport to brain ... InfectiousDiseases #Diagnosis
Causes of Acute Onset Fever - Differential Diagnosis Algorithm Viral: • Rhinovirus • Influenza Virus • Parainfluenza
- Differential Diagnosis ... Algorithm Viral ... Infectious - Other: • Fungal ... eg.malaria) • Other parasites ... #Algorithm #causes
Causes of Encephalopathy - Differential Diagnosis Algorithm Hyperacute: - Primary Neurologic: Vascular (IS, ICH), Seizure, Migraine, Trauma
- Differential Diagnosis ... Algorithm Hyperacute ... Neoplasm-related (brain ... Inflammatory, Infectious (fungal ... , TB, parasitic,
Approach to Eosinophilic Lung Diseases • Acute Eosinophilic Pneumonia (< 1 wk) - ~30yo, M; Recent
brown sputum, fever ... Infectious (Variable) - Fungal ... , parasites; Travel ... #differential #diagnosis ... #comparison #table
Fungal Biomarkers: Beta-D-Glucan and Aspergillus Galactomannan Beta-D-Glucan: • Polysaccharide cell wall component of many fungi • Pathogens:
Fungal Biomarkers ... Polysaccharide cell wall component ... post-2010 almost never ... Galactomannan #diagnosis ... #comparison
Lung Abscess - Diagnosis and Management Summary Lung Abscess Etiology: • Necrosis of lung parenchyma by a
Lung Abscess Pathophysiology ... : • 80% have fever ... Intervention: - Fevers ... Prevotella • Fungal ... Coccidioides • Parasite
Mycoses HISTOPLASMOSIS • Inhalation of conidia → Yeast → travel to lymph nodes → spread in body • Bird
respiratory symptoms • Fever ... infection • Cough, fever ... Aspergillosis Pathophysiology ... • Sinusitis • Brain ... • Isolated fever
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