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causes differential infections infectiousdiseases lung management abscess acute aspergillus bacteremia betadglucan biomarkers chronic comparison encephalopathy fuo galactomannan mycoses pulmonary pyrogen
Fever - Pyrogen Pathophysiology EXOGENOUS PYROGEN • Bacteria: Lipopolysaccharide components, peptidoglycans and muramyl peptide derivatives, Toxins •
Pathophysiology ... Lipopolysaccharide components ... stranded RNA • Fungi ... - Transport to brain ... #Fever #Pathophysiology
Causes of Fever of Unknown Origin (FUO) - Differential Diagnosis Algorithm Neoplasm: • NHL • Hodgkin's lymphoma • Leukemia • Solid
- Differential Diagnosis ... Algorithm Neoplasm ... Infection: • Fungal ... malaria) • other parasites ... #Algorithm #causes
Rigors And Bacteremia - Overview • Rigors are a response to the release of cytokines and prostaglandins
hypothalamus → fever ... PATHOPHYSIOLOGY: ... Double-stranded RNA • Fungi ... Transport to brain ... InfectiousDiseases #Diagnosis
Differential Diagnosis for Concurrent Brain and Lung Infections • Bacteria: Strep anginosus, Staph aureus, Klebsiella pneumoniae
Differential Diagnosis ... for Concurrent ... Brain and Lung Infections ... tuberculosis, NTM • Parasite ... Toxoplasmosis • Fungi
Causes of Acute Onset Fever - Differential Diagnosis Algorithm Viral: • Rhinovirus • Influenza Virus • Parainfluenza
- Differential Diagnosis ... Algorithm Viral ... Infectious - Other: • Fungal ... eg.malaria) • Other parasites ... #Algorithm #causes
Concurrent Brain and Lung Lesions • Bacteria: Nocardia spp, Strep anginosus, Staph aureus, Klebsiella pneumoniae (hypervirulent),
Concurrent Brain ... ) • Fungi: Aspergillus ... Coccidioides • Parasite ... febrilepodcast #Brain ... #Differential #Diagnosis
Concurrent Brain and Lung Lesions • Bacteria: Nocardia spp, Strep anginosus, Staph aureus, Klebsiella pneumoniae (hypervirulent),
Concurrent Brain ... ) • Fungi: Aspergillus ... Coccidioides • Parasite ... febrilepodcast #Brain ... #Differential #Diagnosis
Causes of Encephalopathy - Differential Diagnosis Algorithm Hyperacute: - Primary Neurologic: Vascular (IS, ICH), Seizure, Migraine, Trauma
- Differential Diagnosis ... Algorithm Hyperacute ... Neoplasm-related (brain ... Inflammatory, Infectious (fungal ... , TB, parasitic,
Fungal Biomarkers: Beta-D-Glucan and Aspergillus Galactomannan Beta-D-Glucan: • Polysaccharide cell wall component of many fungi • Pathogens:
Fungal Biomarkers ... Polysaccharide cell wall component ... decreased with: concurrent ... post-2010 almost never ... Galactomannan #diagnosis
Lung Abscess - Diagnosis and Management Summary Lung Abscess Etiology: • Necrosis of lung parenchyma by a
Lung Abscess Pathophysiology ... : • 80% have fever ... Intervention: - Fevers ... Prevotella • Fungal ... Coccidioides • Parasite
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