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diagnosis differential infections endocarditis lung bcnie betadglucan brain cardiology culture galactomannan infective management abscess aids biomarkers bloodculture bloodcultures chest clinical
Causes of Culture Negative Abscess - Differential Diagnosis Framework Consider prior antibiotics as a cause of a
Causes of Culture ... Negative Abscess ... antibiotics as a cause ... of a negative culture ... Differential #Diagnosis #InfectiousDiseases
Fungal Biomarkers: Beta-D-Glucan and Aspergillus Galactomannan Beta-D-Glucan: • Polysaccharide cell wall component of many fungi • Pathogens:
Fungal Biomarkers ... Polysaccharide cell wall component ... Coccidioides - Negative ... Cryptococcus - Negative ... decreased with: concurrent
Transplant Infections Timeline Pre-transplant: • Common bacteria (endogenous): Staphylococci (skin), Gram-negative bacilli (gut) • Viruses: HSV (reactivation) Engraftment:
Staphylococci (skin), Gram-negative ... (mucosa), Aspergillus ... : Aspergillus spp ... differential #diagnosis #causes ... #infectiousdiseases
Causes of blood culture negative infective endocarditis Bartonella spp, Brucella spp, Coxiella burnetii, Chlamydia spp, Tropheryma whipplei,
culture negative ... Tropheryma whipplei, Fungi ... (Aspergillus, Candida ... #culture #negative ... #Endocarditis #InfectiousDiseases
1,3-Beta-D-Glucan and Galactomannan Testing Sensitivity Specificity and False Positives 1,3-Beta-D-Glucan • Cell wall component of many fungi
• Cell wall component ... of many fungi ... Almost always negative ... Sensitivity ↓ w/concurrent ... closely related fungi
My Patient with Infective Endocarditis (IE) Has Negative Blood Cultures - Did they receive antibiotics prior
therapy - Number one cause ... of culture negative ... Fungal (Histoplasma ... /Aspergillus) / ... Diagnosis #Management #Algorithm
Concurrent Brain and Lung Lesions • Bacteria: Nocardia spp, Strep anginosus, Staph aureus, Klebsiella pneumoniae (hypervirulent),
Concurrent Brain ... ) • Fungi: Aspergillus ... Lung #Infections #Concurrent ... Differential #Diagnosis #causes ... #infectiousdiseases
Concurrent Brain and Lung Lesions • Bacteria: Nocardia spp, Strep anginosus, Staph aureus, Klebsiella pneumoniae (hypervirulent),
Concurrent Brain ... ) • Fungi: Aspergillus ... Lung #Infections #Concurrent ... Differential #Diagnosis #causes ... #infectiousdiseases
Invasive Aspergillus (IA) - Diagnosis and Management Aspergillus is ubiquitous in nature. Most invasive infections are caused
infections are caused ... presentations: • Pulmonary ... considered in certain cases ... Management #treatment #fungal ... #infectiousdiseases
Blood Culture-Negative Infective Endocarditis (BCNIE) Definition: No etiology found after 3 separate blood cultures remain negative for
Blood Culture-Negative ... cultures remain negative ... but important causes ... (Aspergillus, Candida ... differential #workup #infectiousdiseases
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