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diagnosis differential management endocarditis microbiology treatment activetb bcnie betadglucan cardiology causes galactomannan infections infective laboratory latenttb tb tuberculosis arthritis aspergillus
Microorganisms Responsible for Infective Endocarditis Native valves: - Streptococcus viridans - Enterococci - Other streptococci
epidermidis - Gram-negative ... bacilli - Fungi ... bacilli - Fungi ... #Endocarditis #Bacteria ... #Differential #InfectiousDiseases
Rigors And Bacteremia - Overview • Rigors are a response to the release of cytokines and prostaglandins
Rigors And Bacteremia ... Lipopolysaccharide components ... Double-stranded RNA • Fungi ... Mannan and glucan components ... Pathophysiology #InfectiousDiseases
Transplant Infections Timeline Pre-transplant: • Common bacteria (endogenous): Staphylococci (skin), Gram-negative bacilli (gut) • Viruses: HSV (reactivation) Engraftment:
Pre-transplant: • Common bacteria ... Staphylococci (skin), Gram-negative ... Staphylococci (skin), Gram-negative ... difficile (gut) • Fungi ... diagnosis #causes #infectiousdiseases
Bacteremia Quick Reference - Treatment Duration Gram Negative Bacteremia: • Avoid: Aminoglycosides and tigecycline • Catheters should
Duration Gram Negative ... • Catheters should ... blood cultures are negative ... at 24 hours are negative ... Management #Duration #infectiousdiseases
Causes of blood culture negative infective endocarditis Bartonella spp, Brucella spp, Coxiella burnetii, Chlamydia spp, Tropheryma whipplei,
blood culture negative ... Tropheryma whipplei, Fungi ... under BCNIE, these bacteria ... should grow and ... #Endocarditis #InfectiousDiseases
Blood Culture-Negative Infective Endocarditis (BCNIE) Definition: No etiology found after 3 separate blood cultures remain negative for
Blood Culture-Negative ... cultures remain negative ... or fungi (grows ... should grow and ... differential #workup #infectiousdiseases
(1,3)-β-d-glucan Abundant cell wall polysaccharide, found in most fungi, except cryptococci, zygomycetes (mucor, rhizophus) and blastomyces. Sensitivity 64%-93%;
found in most fungi ... 87%-100% False Negatives ... blood • Certain fungus ... Positives: • Bacteremia ... #microbiology #infectiousdiseases
Fungal Biomarkers: Beta-D-Glucan and Aspergillus Galactomannan Beta-D-Glucan: • Polysaccharide cell wall component of many fungi • Pathogens:
Fungal Biomarkers ... Polysaccharide cell wall component ... Coccidioides - Negative ... synthetic now and should ... Cryptococcus - Negative
Soil Related Infections - Differential Diagnosis Framework Mechanism Of Infection: • Wound • GI: Ingestion, MUD, Contaminated
rhizosphere include: bacteria ... , fungi, oomycetes ... arthropods Bacteria ... or sinus fungus ... differential #diagnosis #InfectiousDiseases
CAPD-associated peritonitis (Continuous Ambulatory Peritoneal Dialysis) - 5 Things To Know Diagnosis (Two of the following): (1) Clinical
• 15-35% Gram negative ... Polymicrobial should ... peritonitis • Fungal ... prior abx use, fungal ... Diagnosis #Management #InfectiousDiseases
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