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Nephron Pathophysiology Study Guide 

- Proximal Tubule
- Loop of Henle
- Distal Tubule
- Collecting Duct

The Kidney Zone

#Nephron
Nephron Pathophysiology ... - Collecting Duct ... Kidney Zone #Nephron ... #Nephrology #Pathophysiology ... #Duct #LoopOfHenle
Nephron Schematic Map - Colombia Nephrology

#Nephron #Nephrology #Pathophysiology #Overview #Tubules #Duct #LoopOfHenle #Diuretics #Schematic #Map
#Nephron #Nephrology ... #Pathophysiology ... #Overview #Tubules ... #Duct #LoopOfHenle ... #Diuretics #Schematic
Nephron Physiology and Transporters
 • Proximal Tubule
 • Thick Ascending Limb
 • Distal Convoluted Tubule
 •
Nephron Physiology ... Distal Convoluted Tubule ... Cortical Collecting Duct ... #Nephron #pathophysiology ... #Transporters #nephrology
Nephron Reabsorption Sites
 • Proximal Convoluted Tubule
 • Proximal Straight Tubule
 • Thick Ascending Limb
 •
Nephron Reabsorption ... • Collecting Duct ... • Bladder #Nephron ... #Reabsorption #pathophysiology ... #nephrology
Major Segments of the Nephron and their Functions 
 - Glomerulus - Formation of glomerular filtrate
Segments of the Nephron ... acid and most diuretics ... Medullary collecting duct ... vasopressin control #Nephron ... Segments #Function #Pathophysiology
Diuretics - Pharmacology

Thiazides diuretics:
 • Inhibit Na+ Cl- cotransporter in distal tubule
 • Chlorothiazide, Chlorthalidone, Indapamide,
cotransporter in distal tubule ... the collecting duct ... in the proximal tubule ... loss through the nephron ... the collecting duct
Mechanisms of nephron damage in cardiorenal syndrome
 • Increased renal interstitial pressure
 • Hypoperfusion
 • Reduced
Mechanisms of nephron ... damage • Tubular ... activities • Diuretic ... syndrome #Mechanisms #pathophysiology ... #nephrology
Hypochloremia - Differential Diagnosis Algorithm

Cause - Decreased Intake:
 • Low salt in diet
 • Exclusive D5W
Differential Diagnosis Algorithm ... RENAL LOSS: - Diuresis ... filtration rate by tubulo-glomerular ... Cl⁻ with other components ... #Pathophysiology
Gitelman Syndrome Overview

What?
• Inherited (AR) hypokalemic salt-losing tubulopathies affecting the thiazide-sensitive sodium chloride cotransporter
• Gitelman's syndrome
distal convoluted tubule ... (DCT) Clinical ... with thiazide diuretic ... Surreptitious diuretic ... #management #pathophysiology