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differential rheumatology management sodium druginduced hypernatremia sle table antiphospholipid apls comparison dermatology dil erythematosus glomerulonephritis hypercoagulable hypokalemia hypotonic petechiae petechial
Diagnostic Approach to Hyponatremia Box A: • Normo/hyperosmolar Hyponatremia: Glucose, Mannitol, Glycine, Contrast media, Maltose • Pseudohyponatremia:
Diagnostic Approach ... Somnolence, Seizures, Confusion ... Primary Polydipsia, Low ... #Diagnosis #Algorithm ... #workup
Hyponatremia Diagnosis Algorithm UOsm ≥ POsm - Vasopressin-Dependent • UNa < 20 mEq/L - Appropriate (↓ EABV)
Hyponatremia Diagnosis ... Algorithm UOsm ... Primary polydipsia, Low ... #algorithm #causes ... #nephrology
Hypernatremia - Differential Diagnosis Workup Algorithm 1) Check Urine Osmolality: > 600 mOsm/kg - Implies extrarenal mechanism
Differential Diagnosis ... Workup Algorithm ... • Euvolemic (Low ... #Workup #Algorithm ... #nephrology #sodium
Hyponatremia - Differential Diagnosis Algorithm ADH Independent: • Tea and Toast Syndrome, Beer Potomania - Low solute
Hyponatremia - Differential ... Diagnosis Algorithm ... Beer Potomania - Low ... #Algorithm #causes ... #nephrology
Causes of Hypernatremia - Differential Diagnosis Algorithm Hypernatremia - Excess free water loss, Serum Sodium >145 mmol/L High
Causes of Hypernatremia ... Algorithm Hypernatremia ... mannitol, glucosuria Low ... #Nephrology #Differential ... #Diagnosis #Algorithm
Causes of Hypokalemia - Differential Diagnosis Algorithm Once pseudohypokalemia is ruled out, causes of hypokalemia can be
- Differential Diagnosis ... Algorithm Once ... filling of bucket (low ... #Algorithm #Causes ... #workup #nephrology
Systemic Lupus Erythematosus (SLE) - Diagnosis and Management Summary • Epidemiology: 10-180/100,000, Typically Age 20-40, F:M
(SLE) - Diagnosis ... • Immunologic Workup ... Positive in 60-80% of cases ... 60-80% - Low ... Erythematosus #Diagnosis
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
• Immunologic Workup ... in >90% - Low ... • Immunologic Workup ... 60-80% - Low ... #diagnosis #management
Rapidly Progressive Glomerulonephritis (RPGN) RPGN has three primary pathophysiologic causes differentiated by immunofluorescence Immune Complex Mediated (granular staining):
pathophysiologic causes ... staining): • Low ... Post-strep GN, Lupus ... #differential #diagnosis ... #algorithm #rheumatology
Physiologic Approach to Hypotonic Hyponatremia The next time you have a case of hypotonic hyponatremia, give the
time you have a case ... normal volume-based algorithm ... can be high or low ... #differential #diagnosis ... table #sodium #nephrology
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