12 results
Metformin - First Line Treatment for Diabetes Type 2
• Start with initial dose of 500 mg
Start with initial dose ... daily • Adjust dose ... Increase dose gradually ... highest dose tolerable ... Diabetes #DM2 #Prescribing
Metformin 
Current Renal Dose Adjustments due to Risk of Lactic Acidosis 
> 60 No adjustment 
45-60
Renal Dose Adjustments ... , consider 50% dose ... #Renal #Dosing ... #Dose #Pharmacology ... #Diabetes
ACEI Antihypertensive Dose Comparison. Consider divided (BID) regimen for better pre-dose (trough) BP control for the
Antihypertensive Dose ... for better pre-dose ... potassium, and renal ... #Conversion #Pharmacology ... #Hypertension #Management
DPP4 Inhibitors - Normal and Renal Dosing

Increase Incretins (GLP-I & GIP) -> Stimulates Insulin, Inhibits Glucagon
on the highest dose ... only use lower doses ... at the lowest dose ... #Dosing #Pharmacology ... #Management #Diabetes
Metformin: Biguanide
Metformin is the first-line medication for treatment of type 2 diabetes. It is very effective
first-line medication ... titrating the dose ... until at optimal dose ... attention to patients renal ... #Pharmacology #
Diabetes Mellitus Type 2 Inpatient Medication Guide

Classes: Biguanide, Sulfonylurea, TZD, DPP-4 inhibitor, GLP-1 receptor agonist, SGLT2i,
Calculate total daily dose ... Adjust insulin dose ... #Mellitus #DM2 ... #pharmacology # ... comparison #table
Management of Diabetes Mellitus in Patients With CKD

1. Monitor for changes in BP, serum creatinine, &
Management of Diabetes ... increase in the dose ... an increase in dose ... ml/min per 1.73 m2 ... evidence-based pharmacologic
GLP-1 Medications: Ozempic vs. Trulicib (semaglutide vs. dulaglutide) 

From my experience, Ozempic and Trulicity are the
GLP-1 Medications ... Both are weekly dosed ... week onboarding dose ... not require dose ... #Diabetes #Comparison
Lyrica (Pregabalin) 
Indications: Neuropathy (diabetic, postherpetic neuralgia, fibromyalgia, & spinal cord injury), Adjunctive therapy for partial-onset
: Neuropathy (diabetic ... partial-onset seizures Dosing ... Adjust based on renal ... to be renally dose ... Lyrica #Pregabalin #Pharmacology
Tuberculosis Dosing Recommendations for Adult Patients With Reduced Renal Function (CKD)
Isoniazid 300 mg once daily, or
Tuberculosis Dosing ... Patients With Reduced Renal ... #Tuberculosis #Dosing ... #CKD #pharmacology ... #medications #management