7 results
Hypernatremia Differential Diagnosis Algorithm - Diabetes Insipidus Workup

Step #1 - Consider the history
Step #2 - Assess
- Diabetes Insipidus ... Workup Step #1 ... history Step #2 ... #Sodium #nephrology ... #insipidus #DI
Polyuria - Differential Diagnosis Algorithm
Polyuria = >3L Urine output / 24 hours
Urine osmolality = 2 (Na
Polyuria - Differential ... Urine osmolality = 2 ... 100 mosm/kg • Diabetes ... Insipidus • Primary ... #nephrology
Causes of Hypernatremia - Differential Diagnosis Algorithm
Hypernatremia - Excess free water loss, Serum Sodium >145 mmol/L
High
water loss, Serum Sodium ... diuresis (see Polyuria ... 300 mmol/kg • Diabetes ... Insipidus Hypodipsia ... Hypernatremia #Nephrology
Diabetes Insipidus - Diagnosis Algorithm
Tests:
 • Osmolality, Urine AND/OR
 • Osmolality, Serum or Plasma AND
 •
Diabetes Insipidus ... Plasma AND • Sodium ... Osmolality, Urine 1- ... #Algorithm #nephrology ... #differential
Hypernatremia - Differential Diagnosis Workup Algorithm

1) Check Urine Osmolality:
 > 600 mOsm/kg - Implies extrarenal mechanism
1) Check Urine ... renal mechanism 2) ... • Euvolemic: Diabetes ... insipidus (central ... #nephrology #sodium
Inherited Defects in Kidney Tubule Epithelial Cells

Renal glucosuria - Na+-dependent glucose cotransporter
Cystinuria - Amino acid transporter
Bartter
ATPase Nephrogenic diabetes ... insipidus - Vasopressin ... Defects #Kidney #Nephrology ... #Diagnosis #Differential ... #Table
Hypernatremia - Differential Diagnosis and Treatment
Hypernatremia is almost always due to unreplaced water loss (free water
urine osm (in DI ... water unavailable 2) ... post-obstructive 3) Diabetes ... Insipidus: neurogenic ... #sodium